| Identification | Back Directory | [Name]
6-METHOXYPURINE RIBOSIDE | [CAS]
5746-29-2 | [Synonyms]
Nsc30606
Nsc 30306
6-O-Methylinosine
Inosine, 6-O-methyl-
6-METHOXYPURINE RIBOSIDE
6-Methoxypurine-9-riboside
6-Methoxypurine ribonucleoside
6-Methoxypurine-9-β-D-riboside
6-Methoxypurine-9-beta-D-riboside
6-Methoxypurine 9-beta-D-ribofuranoside
6-Methoxy-9-(beta-D-ribofuranosyl)purine
9H-Purine, 6-methoxy-9-.beta.-D-ribofuranosyl-
6-O-Methylinosine, 6-Methoxypurine-9-beta-D-riboside | [Molecular Formula]
C11H14N4O5 | [MDL Number]
MFCD00056000 | [MOL File]
5746-29-2.mol | [Molecular Weight]
282.25 |
| Chemical Properties | Back Directory | [Melting point ]
140 °C(Solv: methanol (67-56-1); ethyl acetate (141-78-6)) | [Boiling point ]
610.7±65.0 °C(Predicted) | [density ]
1.84±0.1 g/cm3(Predicted) | [pka]
13.08±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
6-O-Methylinosine is a hypoxanthine analogue. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia[1][2]. | [Definition]
ChEBI: 6-O-methylinosine is inosine carrying a methyl substituent on the oxygen at position 6 on the hypoxanthine ring. It has a role as a metabolite. It is functionally related to an inosine. | [References]
[1] Virág L, Szabó C. Purines inhibit poly(ADP-ribose) polymerase activation and modulate oxidant-induced cell death. FASEB J. 2001 Jan;15(1):99-107. DOI:10.1096/fj.00-0299com
[2] Saugstad OD. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res. 1988 Feb;23(2):143-50. DOI:10.1203/00006450-198802000-00001 |
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