| Identification | Back Directory | [Name]
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-2-amino-2-(1,4-cyclohexadien-1-yl)acetyl]amino]-3-methyl-8-oxo-, sodium salt (1:1), (6R,7R)- | [CAS]
57584-26-6 | [Synonyms]
Cephradine sodium
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-2-amino-2-(1,4-cyclohexadien-1-yl)acetyl]amino]-3-methyl-8-oxo-, sodium salt (1:1), (6R,7R)- | [Molecular Formula]
C16H20N3NaO4S | [MOL File]
57584-26-6.mol | [Molecular Weight]
373.4 |
| Hazard Information | Back Directory | [Uses]
Cephradine sodium is a broad-spectrum and orally active cephalosporin. Cephradine sodium is active against both gram-positive and gram-negative pathogens. Cephradine sodium is effective in eradicating most penicillinase-producing organisms. Cephradine sodium has been used in the research of genitourinary, gastrointestinal and respiratory tract infections, and in infections of the skin and soft tissues. Cephradine sodium blocks solar-ultraviolet induced skin inflammation through direct inhibition of TOPK[1][2][3]. | [References]
[1] Schwinghammer TL, et al. Pharmacokinetics of cephradine administered intravenously and orally to young and elderly subjects. J Clin Pharmacol. 1990;30(10):893-899 DOI:10.1002/j.1552-4604.1990.tb03568.x
[2] Caloza DL Jr, et al. Intravenous use of cephradine and cefazolin against serious infections. Antimicrob Agents Chemother. 1979;15(1):119-122. DOI:10.1128/AAC.15.1.119
[3] Fan X, et al. Cefradine blocks solar-ultraviolet induced skin inflammation through direct inhibition of T-LAK cell-originated protein kinase. Oncotarget. 2016;7(17):24633-24645 DOI:10.18632/oncotarget.8260
[4] Kang S, et al. In Vitro and In Vivo Antimicrobial Activity of Antibiotic-Conjugated Carriers with Rapid pH-Responsive Release Kinetics. Adv Healthc Mater. 2019;8(14):e1900247. DOI:10.1002/adhm.201900247 |
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