| Identification | Back Directory | [Name]
Cyclopentane-1,2-dicarboximude | [CAS]
5763-44-0 | [Synonyms]
Gliclazide Impurity 18
Sodium 2-ethyl-3-oxobutanoate
Cyclopentane-1,2-dicarboximude
CYCLOPENTANE-1,2-DICARBOXIMIDE
1,2-Cyclopentane Dicarboximide
1,2-Cyclopentane Ddicarboximude
CYCLOPENTANE O-DICARBOXYLICIMIDE
SODIUM ACETATE TRIHYDRATE BP ACS USP
Tetrahydrocyclopenta[c]pyrrole-1,3(2H,3aH)
N-methylcarbamic acid (2-acetylphenyl) ester
1,2-cycloglutarimide / glipizide intermediate
tetrahydrocyclopenta[c]pyrrole-1,3(2H,3aH)-dione
Cyclopenta[c]pyrrole-1,3(2H,3aH)-dione, tetrahydro-
4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione
4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-quinone
4,5,6,6a-Tetrahydrocyclopenta[c]pyrrole-1,3(2H,3aH)-dione | [EINECS(EC#)]
227-285-6 | [Molecular Formula]
C7H9NO2 | [MDL Number]
MFCD06411094 | [MOL File]
5763-44-0.mol | [Molecular Weight]
139.15 |
| Chemical Properties | Back Directory | [Melting point ]
168 °C (dec.) | [Boiling point ]
322.2±11.0 °C(Predicted) | [density ]
1.242±0.06 g/cm3(Predicted) | [vapor pressure ]
0.017-0.031Pa at 20-25℃ | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Acetonitrile (Slightly), Chloroform (Slightly) | [form ]
Solid | [pka]
11.97±0.20(Predicted) | [color ]
White to Off-White | [InChI]
InChI=1S/C7H9NO2/c9-6-4-2-1-3-5(4)7(10)8-6/h4-5H,1-3H2,(H,8,9,10) | [InChIKey]
QCWDCTDYSDJKTP-UHFFFAOYSA-N | [SMILES]
N1C(=O)C2CCCC2C1=O | [Surface tension]
71.9mN/m at 1g/L and 20℃ |
| Hazard Information | Back Directory | [Uses]
1,2-Cyclopentanedicarboximide was used as a reactant for [(benzopyranyl)amino]alkyl]azabicyclooctanedione anxiolytic, | [Synthesis]
The general procedure for the synthesis of 1,2-cyclopentanedicarboxylic acid and formamide (CAS: 77287-34-4) as raw materials for the synthesis of 1,2-cyclopentanedicarboxylic acid is as follows: 50 g of 1,2-cyclopentanedicarboxylic acid and 15 g of formamide were mixed, and the reaction was carried out by raising the temperature up to 170 °C under the protection of nitrogen while evaporating the low-boiling by-products. The reaction progress was monitored by HPLC and terminated when the residual amount of raw material was less than 0.2%. After the reaction solution was cooled to 80 °C, 50 g of deionized water and 0.5 g of activated carbon were added and stirred at 50 °C for 30 min. The reaction mixture was thermally filtered and the filtrate was cooled to 20 °C and extracted with dichloromethane. The organic phase was concentrated to no fraction and dried at 90 °C. Subsequently 100 g of toluene was added, the mixture was cooled to 5 °C and dried under reduced pressure at 40 °C to give about 60.6 g of white crystal product. The yield of this step was 93.5% and the product was ≥99% pure and ≥98% content. | [References]
[1] Patent: CN106866495, 2017, A. Location in patent: Paragraph 0016; 0017; 0018; 0019; 0020 |
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