| Identification | Back Directory | [Name]
CHITOBIOSE DIHYDROCHLORIDE | [CAS]
577-76-4 | [Synonyms]
Chitosanbiose
Chitobiose 2HCl
Chitotriose 2HCl
Chitobiose Hydrochloride
Chitobiose Hydrochlorlde
CHITOBIOSE DIHYDROCHLORIDE
beta-D-glucosaminyl-(1->4)-aldehydo-D-glucosamine
4-O-(2-Amino-2-deoxy-beta-D-glucosyl)-D-glucosamine
D-Glucose, 2-amino-4-O-(2-amino-2-deoxy-β-D-glucopyranosyl)-2-deoxy-
D-Glucose, 2-amino-4-o-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-
N-[5-[3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,4-dihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide
(3R,4R,5S,6R)-3-amino-5-(((2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-2,4-diol | [Molecular Formula]
C12H26Cl2N2O9 | [MDL Number]
MFCD06801377 | [MOL File]
577-76-4.mol | [Molecular Weight]
413.25 |
| Hazard Information | Back Directory | [Chemical Properties]
reducing terminal of N-linked oligosaccharides, lectin inhibitor, lysozyme substrate | [Uses]
Chitobiose, a chitosan oligosaccharide, is a dimer of β-1,4-linked glucosamine units[1]. Chitobiose has orally activity and high antioxidant activity[2]. | [Definition]
ChEBI: Beta-D-glucosaminyl-(1->4)-aldehydo-D-glucosamine is a member of chitobioses. | [in vivo]
Chitobiose (30, 100, 300 mg/kg; p.o., single) can enters the circulatory system when given orally[2].
Pharmacokinetic Parameters of Chitobiose in Wistar strain male rats[2].
| PO (30 mg/kg) | PO (100 mg/kg) | PO (300 mg/kg) | | Tmax (h) | 0.9 | 1.0 | 1.8 | | Cpmax (μg/mL) | 1.1 | 4.4 | 6.9 | | AUC0-4h (μg·h/mL) | 2.5 | 9.0 | 17.6 | | AUMC0-4h (μg·h^2/mL) | 4.0 | 13.2 | 35.6 | | MRT (h) | 1.6 | 1.5 | 1.6 | | MAT (h) | 1.1 | 1.0 | 1.2 | | ka (h^-1) | 0.95 | 0.99 | 0.96 | | F1-4h (%) | 1.8 | 2.0 | 1.3 |
| Animal Model: | Wistar strain male rats (7 weeks, 165-185 g)[2] | | Dosage: | 30, 100, 300 mg/kg | | Administration: | p.o., single (Pharmacokinetics analysis) | | Result: | Entered the circulatory system when given orally. |
| [References]
[1] Zhao Q, et al. Chitoheptaose Promotes Heart Rehabilitation in a Rat Myocarditis Model by Improving Antioxidant, Anti-Inflammatory, and Antiapoptotic Properties. Oxid Med Cell Longev. 2020;2020:2394704. Published 2020 Apr 11. DOI:10.1155/2020/2394704
[2] Chen AS, Taguchi T, Okamoto H, et al. Pharmacokinetics of chitobiose and chitotriose administered intravenously or orally to rats. Biol Pharm Bull. 2005;28(3):545-548. DOI:10.1248/bpb.28.545 |
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