| Identification | Back Directory | [Name]
heptelidic acid | [CAS]
57710-57-3 | [Synonyms]
Avocettin
Koningic acid
heptelidic acid
(5aS,9S)-1,5aβ,6,7,8,9aα-Hexahydro-6β-isopropyl-1-oxospiro[2-benzoxepine-9(3H),2'-oxirane]-4-carboxylic acid
(5aS,9S)-1,5a,6,7,8,9aα-Hexahydro-6β-(1-methylethyl)-1-oxospiro[2-benzoxepine-9(3H),2'-oxirane]-4-carboxylic acid
Spiro[2-benzoxepin-9(3H),2'-oxirane]-4-carboxylic acid, 1,5a,6,7,8,9a-hexahydro-6-(1-methylethyl)-1-oxo-, (2'S,5aS,6R,9aS)- | [Molecular Formula]
C15H20O5 | [MOL File]
57710-57-3.mol | [Molecular Weight]
280.32 |
| Chemical Properties | Back Directory | [Boiling point ]
501.1±50.0 °C(Predicted) | [density ]
1.27±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml | [form ]
A solid | [pka]
3.68±0.40(Predicted) | [color ]
Colorless to off-white | [LogP]
2.034 (est) |
| Hazard Information | Back Directory | [Uses]
Heptalidic acid is a?sesquiterpene lactone and found to inhibit etoposide-induced apoptosis in human leukemia U937 cells. In addition, it also?inhibit mammalian DNA polymerases and terminal deoxynucleotidyl transferase. | [in vivo]
Heptelidic acid (Koningic acid; KA) is bioavailable and induces dynamic changes to glycolysis in vivo[3]. | Animal Model: | 6-week old female Foxn1nu mice bearing BT-474 tumor[3] | | Dosage: | 1, 2.5, 5, and 10 mg/kg | | Administration: | Daily intraperitoneal (IP) injections, 24 hours | | Result: | 1 mg/kg was determined to be the maximum tolerated dose (MTD) based upon behavioral monitoring and adverse events at higher doses (hemolysis, hematuria, and anemia).
|
| [IC 50]
Caspase-3 | [storage]
Store at -20°C |
|
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|