| Identification | Back Directory | [Name]
Montelukast Dicyclohexylamine Salt | [CAS]
577953-88-9 | [Synonyms]
Montelukast raceMate
Montelukast racemate CRS
Montelast dicyclohexylamine
Montelukast Racemate (1446848)
Montelukast racemate (Y0001433)
Montelukast Dicyclohexylamine RS
Montelukast Dicyclohexylamine Salt
Montelukast dicyclohexylamine Impurity
Montelukast Dicyclohexylamine (1446815)
Montelukast Dicyclohexylamine/ Montelukast DCHA
Montelukast dicyclohexylamine salt 577953-88-9
1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneaceticaciddicyclohexylaminesal
1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid dicyclohexylamine salt
1-[1-[[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic N-Cyclohexylcyclohexanamine
Montelukast sodium impurity 8/Montelukast Dicyclohexylamine/1-[1-[[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic N-Cyclohexylcyclohexanamine | [EINECS(EC#)]
611-575-8 | [Molecular Formula]
C47H59ClN2O3S | [MDL Number]
MFCD23160308 | [MOL File]
577953-88-9.mol | [Molecular Weight]
767.51 |
| Chemical Properties | Back Directory | [Melting point ]
65-67°C | [density ]
1.2g/cm3 at 20℃ | [storage temp. ]
-20°C Freezer | [solubility ]
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | [form ]
neat | [color ]
White to Pale Beige | [Major Application]
pharmaceutical
pharmaceutical small molecule | [InChIKey]
ZLOLVGQQYDQBMP-UJCKLGLENA-N | [SMILES]
N(C1CCCCC1)C1CCCCC1.C(C1(CC1)CC(=O)O)S[C@@H](C1C=CC=C(/C=C/C2C=CC3=CC=C(Cl)C=C3N=2)C=1)CCC1C=CC=CC=1C(O)(C)C |&1:22,r| | [LogP]
0.24-4.9 at 20℃ |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H319 | [Precautionary statements ]
P305+P351+P338 | [WGK Germany ]
WGK 3 | [HS Code ]
2933497050 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Aquatic Acute 1
Aquatic Chronic 1 |
| Hazard Information | Back Directory | [Chemical Properties]
Pale Beige Solid | [Uses]
Montelukast Dicyclohexylamine Salt is a selective leukotriene D4-receptor antagonist. Used as an antiasthmatic.
| [in vivo]
Montelukast (3 mg/kg; oral gavage) protects against APAP-induced hepatotoxicity in mice[1].
Montelukast (1 mg/kg; miniosmotic pump administration) reduces the airway remodeling changes observed in OVA-treated mice and blocks the actions of cysteinyl leukotrienes (LT) C4, D4, and E4 mediated by the CysLT1 receptor[2].
Montelukast (1 mg/kg; miniosmotic pump administration) reduces the elevated levels of IL-4 and IL-13 found in the BAL fluid of OVA-treated mice[2]. | Animal Model: | C57BL/6J mice (8-week-old; 22-25 g) are induced acute hepatic injury[1] | | Dosage: | 3 mg/kg | | Administration: | Oral gavage 1 h after saline or APAP administration | | Result: | Decreased serum levels of alanine transaminase (ALT) and aspartate aminotransferase (AST), and alleviated liver damage.
|
| [IC 50]
CysLT1 |
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