| Identification | Back Directory | [Name]
AC-GLY-ALA-LYS(AC)-AMC | [CAS]
577969-56-3 | [Synonyms]
Ac-GAK(Ac)-AMC
AC-GLY-ALA-LYS(AC)-AMC
acetyl-Gly-Ala-(N-acetyl-Lys)-AMC
N-Acetylglycyl-L-alanyl-N6-acetyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-lysinamide
L-Lysinamide, N-acetylglycyl-L-alanyl-N6-acetyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)- | [Molecular Formula]
C25H33N5O7 | [MDL Number]
MFCD11975032 | [MOL File]
577969-56-3.mol | [Molecular Weight]
515.56 |
| Hazard Information | Back Directory | [Uses]
Ac-Gly-Ala-Lys(Ac)-AMC is a fluorogenic substrate for the determination of protease activity. Ac-Gly-Ala-Lys(Ac)-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal[1]. | [References]
[1] Ptacek J, et, al. Selectivity of Hydroxamate- and Difluoromethyloxadiazole-Based Inhibitors of Histone Deacetylase 6 In Vitro and in Cells. Int J Mol Sci. 2023 Mar 1;24(5):4720. DOI:10.3390/ijms24054720 |
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