57915-78-3

38594-42-2

57915-78-3

General procedure for the synthesis of 2,3-dichlorobenzyl bromide from 2,3-dichlorobenzyl alcohol: Phosphorus tribromide (40.7 g, 0.151 mol) was added slowly and dropwise to a solution of 2,3-dichlorobenzyl alcohol (75 g, 0.431 mol) in toluene (800 ml) at room temperature with continuous stirring. The reaction mixture was continued to be stirred at room temperature for 2 hours and then concentrated. The concentrated residue was neutralized with aqueous sodium bicarbonate and subsequently extracted with dichloromethane (300 ml x 3). The organic layer was washed with brine, dried over anhydrous sodium sulfate, filtered and the filtrate was concentrated to give 2,3-dichlorobenzyl bromide (84.7 g, 83% yield) as a dark solid.