57947-01-0

77925-51-0

57947-01-0

General method: LiAlH4 (5 mmol) was slowly added to a stirred ether suspension of TiCl4 (1 mmol). The resulting suspension was stirred continuously for 15 minutes at room temperature. Subsequently, an ether solution of nitro compounds (1a, 1 mmol) was added dropwise to the above black reducing suspension under nitrogen protection. The reaction mixture was stirred at room temperature and the progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent was ether/petroleum ether, 60:40 v/v). After complete conversion of the raw materials, the reaction mixture was filtered through filter paper and washed sequentially with 1N NaOH aqueous solution (3 x 5 mL) and brine (5 mL). The organic layer was dried with anhydrous Na2SO4 and concentrated to dryness under reduced pressure to afford the target product 2-amino-N,N-diethylbenzenesulfonamide.