| Identification | Back Directory | [Name]
BAX INHIBITING PEPTIDE V5 (BIP-V5) | [CAS]
579492-81-2 | [Synonyms]
Val-Pro-Met-Leu-Lys
VAL-PRO-MET-LEU-LYS;BIP-V5
BAX INHIBITOR PEPTIDE V5, >99%
Bax inhibitor peptide V5 (BIP-V5)
BAX INHIBITING PEPTIDE V5 (BIP-V5)
L-Lysine, L-valyl-L-prolyl-L-methionyl-L-leucyl-
VAL-PRO-MET-LEU-LYS;BIP-V5;BAX INHIBITING PEPTIDE V5
BAX Inhibiting Peptide V5 >=97% (HPLC), lyophilized powder
Bax inhibitor peptide V5,Val-Pro-Met-Leu-Lys, BIP-V5,BAX Inhibiting Peptide V5, >99% | [Molecular Formula]
C27H50N6O6S | [MDL Number]
MFCD04974826 | [MOL File]
579492-81-2.mol | [Molecular Weight]
586.79 |
| Chemical Properties | Back Directory | [Boiling point ]
907.2±65.0 °C(Predicted) | [density ]
1.185±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
≥29.35 mg/mL in DMSO; insoluble in EtOH; ≥91.4 mg/mL in H2O | [form ]
lyophilized powder
| [pka]
3.31±0.10(Predicted) | [color ]
White to off-white | [InChIKey]
NHMUTADCTDDWPV-YFNVTMOMSA-N | [SMILES]
S(CC[C@H](NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)O)C |
| Hazard Information | Back Directory | [Description]
Bax inhibitor peptide V5 is an inhibitor of Bax.1 It decreases levels of the pro-apoptotic proteins Bax, Bad, and NF-ĸB p65 and increases levels of the anti-apoptotic proteins X-linked inhibitor of apoptosis (XIAP) and Bcl-2 in isolated mouse pancreatic islets when used at a concentration of 100 μM.2 It inhibits apoptosis induced by etoposide (Item No. 12092) in Hep3B human hepatoma cells when used at a concentration of 200 μM.1 Bax inhibitor peptide V5 (5 mg/ml, i.c.v.) decreases infarct volume and reduces ipsilateral paw preference in the cylinder rearing test, indicating an improvement in sensorimotor function, in a neonatal mouse model of hypoxic-ischemia brain injury induced by carotid artery ligation.3 Bax inhibitor peptide V5, when used at a concentration of 100 μM in syngeneic pancreatic islet cells prior to transplantation, inhibits increases in blood glucose levels in an intraperitoneal glucose tolerance test and increases survival in a mouse model of diabetes induced by streptozotocin (STZ; Item No. 13104).2 | [Uses]
Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor, used for cancer treatment. | [Biochem/physiol Actions]
BAX Inhibiting Peptide V5 protects Bax against conformational changes and it also prevents mitochondrial translocation. In vitro analysis prove that peptide V5 prevents apoptosis, mediated by a number of agents including staurosporine, ultraviolet and anti-cancer drug. | [in vivo]
Bax inhibitor peptide V5 (BIP-V5; 100 μM) significantly improves islet function following isolation and improves islet graft function following transplantation in mice model[2]. | [IC 50]
Bax | [References]
[1]. sawada m, hayes p, matsuyama s. cytoprotective membrane-permeable peptides designed from the bax-binding domain of ku70. nat cell biol, 2003, 5(4): 352-357.
[2]. rivas-carrillo jd, soto-gutierrez a, navarro-alvarez n, et al. cell-permeable pentapeptide v5 inhibits apoptosis and enhances insulin secretion, allowing experimental single-donor islet transplantation in mice. diabetes, 2007, 56(5): 1259-1267. |
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Sigma-Aldrich
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