Identification | Back Directory | [Name]
BAX INHIBITOR PEPTIDE P5 | [CAS]
579492-83-4 | [Synonyms]
BAX INHIBITOR PEPTIDE P5 L-Glutamic acid, L-prolyl-L-methionyl-L-leucyl-L-lysyl- | [Molecular Formula]
C27H48N6O8S | [MDL Number]
MFCD26792550 | [MOL File]
579492-83-4.mol | [Molecular Weight]
616.77 |
Chemical Properties | Back Directory | [Boiling point ]
1001.4±65.0 °C(Predicted) | [density ]
1.238±0.06 g/cm3(Predicted) | [storage temp. ]
Desiccate at -20°C | [solubility ]
≥61.7 mg/mL in DMSO; ≥101 mg/mL in EtOH with ultrasonic; ≥94.4 mg/mL in H2O | [form ]
solid | [pka]
3.16±0.10(Predicted) |
Hazard Information | Back Directory | [Uses]
Bax Inhibitor Peptide P5 is a cell-permeable pentapeptide based on the Ku70-Bax inhibiting domain. Acts as an effective Inhibitor for Bax-mediated apoptosis (~50-200 uM). | [Biological Activity]
bax inhibitor peptide p5 (bip p5) is a peptide inhibitor of bax translocation to mitochondria [1].bax is a pro-apoptotic member of bcl-2 family proteins and plays an important role in mitochondria-dependent apoptosis. bax stays in the cytosol and transfers into mitochondria after apoptotic stimuli [1].bip p5 is a membrane-permeable peptide inhibitor of bax translocation to mitochondria. in hela cells, bip p5 protected cells from uvc- and sts-induced apoptosis. in u87-mg glioma cells, mcf-7 breast cancer cells and lncap prostate cancer cells, bip p5 also inhibited apoptosis induced by anti-cancer drugs cisplatin, etoposide and doxorubicin. while bip p5 did not suppress uvc- or sts-induced apoptosis in bax-deficient cells (du145), which suggested bip p5 only suppressed bax-mediated apoptosis. the caspase activation and the release of cytochrome c from mitochondria triggered by apoptotic stimuli were also significantly inhibited by bip p5. bip p5 inhibited the interaction of ku70 and endogenous bax in a dose-dependent way [1]. | [storage]
Desiccate at -20°C | [References]
[1]. sawada m, hayes p, matsuyama s. cytoprotective membrane-permeable peptides designed from the bax-binding domain of ku70. nat cell biol, 2003, 5(4): 352-357. |
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