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579492-83-4

579492-83-4 Structure

579492-83-4 Structure
IdentificationBack Directory
[Name]

BAX INHIBITOR PEPTIDE P5
[CAS]

579492-83-4
[Synonyms]

BAX INHIBITOR PEPTIDE P5
L-Glutamic acid, L-prolyl-L-methionyl-L-leucyl-L-lysyl-
[Molecular Formula]

C27H48N6O8S
[MDL Number]

MFCD26792550
[MOL File]

579492-83-4.mol
[Molecular Weight]

616.77
Chemical PropertiesBack Directory
[Boiling point ]

1001.4±65.0 °C(Predicted)
[density ]

1.238±0.06 g/cm3(Predicted)
[storage temp. ]

Desiccate at -20°C
[solubility ]

≥61.7 mg/mL in DMSO; ≥101 mg/mL in EtOH with ultrasonic; ≥94.4 mg/mL in H2O
[form ]

solid
[pka]

3.16±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

Bax Inhibitor Peptide P5 is a cell-permeable pentapeptide based on the Ku70-Bax inhibiting domain. Acts as an effective Inhibitor for Bax-mediated apoptosis (~50-200 uM).
[Biological Activity]

bax inhibitor peptide p5 (bip p5) is a peptide inhibitor of bax translocation to mitochondria [1].bax is a pro-apoptotic member of bcl-2 family proteins and plays an important role in mitochondria-dependent apoptosis. bax stays in the cytosol and transfers into mitochondria after apoptotic stimuli [1].bip p5 is a membrane-permeable peptide inhibitor of bax translocation to mitochondria. in hela cells, bip p5 protected cells from uvc- and sts-induced apoptosis. in u87-mg glioma cells, mcf-7 breast cancer cells and lncap prostate cancer cells, bip p5 also inhibited apoptosis induced by anti-cancer drugs cisplatin, etoposide and doxorubicin. while bip p5 did not suppress uvc- or sts-induced apoptosis in bax-deficient cells (du145), which suggested bip p5 only suppressed bax-mediated apoptosis. the caspase activation and the release of cytochrome c from mitochondria triggered by apoptotic stimuli were also significantly inhibited by bip p5. bip p5 inhibited the interaction of ku70 and endogenous bax in a dose-dependent way [1].
[storage]

Desiccate at -20°C
[References]

[1]. sawada m, hayes p, matsuyama s. cytoprotective membrane-permeable peptides designed from the bax-binding domain of ku70. nat cell biol, 2003, 5(4): 352-357.
Spectrum DetailBack Directory
[Spectrum Detail]

BAX INHIBITOR PEPTIDE P5(579492-83-4)MS
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