| Identification | Back Directory | [Name]
6-BROMOTETRAZOLO[1,5-A]PYRIDINE | [CAS]
5799-75-7 | [Synonyms]
1-(prop-2-ynyl)piperidine
1-(2-Propyn-1-yl)piperidine
1-(Prop-2-yn-1-yl)piperidine
Piperidine, 1-(2-propyn-1-yl)- | [Molecular Formula]
C8H13N | [MDL Number]
MFCD09258642 | [MOL File]
5799-75-7.mol | [Molecular Weight]
123.2 |
| Chemical Properties | Back Directory | [Boiling point ]
55-57 °C(Press: 12 Torr) | [density ]
0.8944 g/cm3 | [pka]
7.78±0.10(Predicted) | [InChI]
InChI=1S/C8H13N/c1-2-6-9-7-4-3-5-8-9/h1H,3-8H2 | [InChIKey]
LQSQLFOKTMSBEC-UHFFFAOYSA-N | [SMILES]
N1(CC#C)CCCCC1 |
| Hazard Information | Back Directory | [Synthesis]
General method: Potassium carbonate (25.41 mmol) was added to an N,N-dimethylformamide (DMF) mixture of 3-bromopropargyl (8.47 mmol) and hexahydropyridine (16.94 mmol), and the reaction mixture was stirred at room temperature for 10-12 hours. After completion of the reaction, the reaction mixture was quenched with ice water and extracted with ethyl acetate. The organic layers were combined and dried over anhydrous sodium sulfate, followed by evaporation of the solvent under reduced pressure to give 1-alkynylpiperidine. | [References]
[1] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 7, p. 1795 - 1801
[2] Organometallics, 2011, vol. 30, # 20, p. 5471 - 5479
[3] European Journal of Medicinal Chemistry, 2015, vol. 99, p. 36 - 50
[4] Journal of the American Chemical Society, 2013, vol. 135, # 34, p. 12627 - 12633
[5] Journal of Medicinal Chemistry, 2001, vol. 44, # 17, p. 2719 - 2734 |
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