| Identification | Back Directory | [Name]
DEBRISOQUIN SULFATE | [CAS]
581-88-4 | [Synonyms]
Tendor
declinax
RO 5-3307
RO 5-33071
DEBRISOQUIN SULFATE
isocaramidinesulfate
DEBRISOQUINE SULFATE
Debrisoquin Hemisulfate
Debrisoquine Hemisulfate
DEBRISOQUINEHEMISULPHATE
Isocaramidine Hemisulfate
3,4-dihydro-2(1h)-isoquinolinecarboxamidinesulfate
3,4-DIHYDRO-2(1H)-ISOQUINOLINECARBOXAMIDINE 0.5 H2SO4
3,4-Dihydro-2(1H)-isoquinolinecarboxamide hemisulfate
3,4-dihydro-2(1h)-isoquinolinecarboxamidinsulfate(2:1)
bis(2-amidino-1,2,3,4-tetrahydroisoquinoline) sulphate
3,4-dihydro-2(1h)-isoquinolinecarboximidamidsulfate(2:1)
3,4-DIHYDRO-2-[1H]-ISOQUINOLINECARBOXAMIDINE SULFATE SALT
3,4-Dihydro-2(1H)-isoquinolinecarboximidamide Hemisulfate
2(1H)-Isoquinolinecarboximidamide, 3,4-dihydro-, sulfate (2:1)
3,4-Dihydro-2(1H)-isoquinolinecarboximidamide, Debrisoquin sulfate, Ro5-33071 | [EINECS(EC#)]
209-472-4 | [Molecular Formula]
C20H28N6O4S | [MDL Number]
MFCD00153791 | [MOL File]
581-88-4.mol | [Molecular Weight]
448.54 |
| Chemical Properties | Back Directory | [Appearance]
Crystalline Solid | [Melting point ]
278-280°, 284-285° or 266-268° (H2O) | [storage temp. ]
-20°C Freezer | [solubility ]
H2O: 20 mg/mL with heat
| [form ]
Solid | [color ]
Pale Yellow |
| Hazard Information | Back Directory | [Chemical Properties]
Crystalline Solid | [Uses]
Antihypertensive | [Originator]
Declinax,Roche,UK,1967 | [Manufacturing Process]
27 g of 1,2,3,4-tetrahydroisoquinoline was added at room temperature to a
solution of 28 g of 2-methyl-2-isothiourea sulfate in 80 ml of water. The
resulting mixture was kept at room temperature with occasional shaking. After
a short period of time, methylmercaptan began to escape, and the mixture
warmed up slightly. After then standing for 24 hours, crystals formed. They
were filtered off and rinsed with ice cold water. Recrystallization from
approximately 100 ml of water yielded 1,2,3,4-tetrahydroisoquinoline-2-
carboxamidine sulfate melting at 278°C to 280°C (uncorr.).
Another batch prepared in the same manner melted at 284°C to 285°C due to
a minute difference in moisture content.
Both batches prepared above analyzed correctly for (C10H13N3)2·H2SO4.
| [Brand name]
Declinax (HoffmannLaRoche). | [Therapeutic Function]
Antihypertensive
| [Biochem/physiol Actions]
Debrisoquine is an anti-hypertensive agent. It is metabolized by cytochrome P4502D6. |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
22 | [Safety Statements ]
26-36 | [WGK Germany ]
3
| [RTECS ]
NW7010000
| [Toxicity]
LD50 in neonate, adult rats (mg/kg): 88 ±18, 1580 ±163 orally (Goldenthal) |
|
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