| Hazard Information | Back Directory | [Description]
Norfunalenone is a polyketide fungal metabolite that has been found in T. stipitatus. | [Uses]
Norfunalenone exhibits weak cytotoxic activity in mouse myeloma NS-1 cell line (ATCC TIB-18) with an IC50 of 70 μM. Norfunalenone also exhibits weak antibacterial activity against B. subtilis (MIC=100 μg/mL; IC50=265 μM)[1]. | [Definition]
ChEBI: 2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one is a carbotricyclic compound that is funalenone in which the methoxy group at position 2 has been demethylated to the corresponding hydroxy derivative. It is a carbotricyclic compound, a member of phenols and an enone. It is a conjugate acid of a 2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one(1-). It derives from a hydride of a phenalene. | [References]
[1] Chaudhary NK, et al. Talauxins: Hybrid Phenalenone Dimers from Talaromyces stipitatus. J Nat Prod. 2020;83(4):1051-1060. DOI:10.1021/acs.jnatprod.9b01066 |
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