| Identification | Back Directory | [Name]
(S)-3,4-Dimethyloxazolidine-2,5-dione | [CAS]
58311-53-8 | [Synonyms]
(S)-3,4-Dimethyloxazolidine-2,5-dione
(4S)-3,4-Dimethyloxazolidine-2,5-dione
2,5-Oxazolidinedione, 3,4-dimethyl-, (4S)-
(L)-3,4-dimethyl-1,3-oxazolidine-2,5-dione
(4S)-3,4-dimethyl-1,3-oxazolidine-2,5-dione | [Molecular Formula]
C5H7NO3 | [MDL Number]
MFCD27925868 | [MOL File]
58311-53-8.mol | [Molecular Weight]
129.11 |
| Chemical Properties | Back Directory | [Boiling point ]
149.5±23.0 °C(Predicted) | [density ]
1.243±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Store in freezer, under -20°C | [pka]
-2.02±0.40(Predicted) | [Appearance]
White to light yellow Solid | [InChI]
InChI=1S/C5H7NO3/c1-3-4(7)9-5(8)6(3)2/h3H,1-2H3/t3-/m0/s1 | [InChIKey]
WTFJJYYGWFKOQH-VKHMYHEASA-N | [SMILES]
O1C(=O)[C@H](C)N(C)C1=O |
| Hazard Information | Back Directory | [Synthesis]
Explosion-proof operation. Synthesis of (S)-3,4-dimethyloxazolidine-2,5-dione: 1 g (6.2 mmol) of the raw material (cas:1085528-19-3) was dissolved in 3 ml of dichloromethane and stirred for 5 min at 20 °C. Subsequently, 500 μl (1.1 eq.) of thionyl chloride was added. The reaction mixture was warmed to 30 °C and maintained at this temperature for 30 min. Upon completion of the reaction, the mixture was concentrated to 1.5 times the original volume and 10 ml of n-heptane was added slowly with continuous stirring. The resulting white solid was cooled to -20°C and stirred at this temperature for 1 hour. The suspension was filtered through a sintered glass funnel and the solid was washed three times with 3 ml of n-heptane. The solid was dried in air for 2 h to give a white acicular product in a yield of 700 mg in 87.4% yield. The structure of the product was confirmed by 1H NMR (DMSO-d6, 400 MHz): δ 1.39 (d, J = 7.5 Hz, 3H); 2.83 (s, 3H); 4.40 (q, J = 7.5 Hz, 1H). | [References]
[1] Patent: US2010/113797, 2010, A1. Location in patent: Page/Page column 3-4 |
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