| Identification | Back Directory | [Name]
CYCLO(-LEU-GLY) | [CAS]
5845-67-0 | [Synonyms]
C(LEU-GLY)
Cyclo(Gly-Leu-)
CYCLO(-LEU-GLY)
CYCLO(L-LEU-GLY)
CYCLO(GLY-L-LEU)
Cyclo(L-leucylglycyl)
Cyclo(glycyl-L-leucyl)
MORPHINE TOLERANCE PEPTIDE
MORPHIN, TOLERANCE PEPTIDE
Cyclo(Gly-L-Leu)≥ 99% (HPLC)
L-Leucylglycine diketopiperazine
3-isobutylpiperazine-2,5-quinone
(S)-3-Isobutylpiperazine-2,5-dione
(S)-3-(2-Methylpropyl)-2,5-piperazinedione
2,5-Piperazinedione,3-(2-methylpropyl)-, (3S)- | [Molecular Formula]
C8H14N2O2 | [MDL Number]
MFCD00076706 | [MOL File]
5845-67-0.mol | [Molecular Weight]
170.21 |
| Chemical Properties | Back Directory | [Melting point ]
255℃ | [Boiling point ]
442.9±38.0 °C(Predicted) | [density ]
1.047 | [storage temp. ]
-15°C | [solubility ]
DMSO (Sparingly), Methanol (Slightly), Water (Slightly) | [form ]
Solid | [pka]
13.22±0.40(Predicted) | [color ]
White to Off-White | [InChI]
1S/C8H14N2O2/c1-5(2)3-6-8(12)9-4-7(11)10-6/h5-6H,3-4H2,1-2H3,(H,9,12)(H,10,11)/t6-/m0/s1 | [InChIKey]
VQFHWKRNHGHZTK-LURJTMIESA-N | [SMILES]
CC(C)C[C@@H]1NC(=O)CNC1=O |
| Safety Data | Back Directory | [Risk Statements ]
43 | [Safety Statements ]
36/37 | [WGK Germany ]
WGK 3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Skin Sens. 1 |
| Hazard Information | Back Directory | [Chemical Properties]
White powder | [Uses]
Cyclo(Leu-Gly) is an antimicrobial compound produced by Latobacillus plantarum. | [in vivo]
Cyclo(glycyl-L-leucyl) (8 mg/kg; s.c.) given 24h after apomorphine (APO) attenuates the DA receptor supersensitivity caused by acute high dose APO (5 mg/kg; s.c.)[1]. | Animal Model: | Male Swiss-Webster mice, 20-25g[1] | | Dosage: | 8 mg/kg | | Administration: | SC; single dose given 24h after apomorphine (APO) | | Result: | Attenuated the DA receptor supersensitivity caused by acute high dose APO (5 mg/kg; s.c.).
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| [IC 50]
Dopamine Receptor |
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