| Identification | Back Directory | [Name]
Quinoline, 2-Methyl-5-[2-[4-(8-quinolinylMethyl)-1-piperazinyl]ethoxy]- | [CAS]
584555-10-2 | [Synonyms]
SB 714786
5-[2-[4-(Quinolin-8-ylmethyl)piperazin-1-yl]ethoxy]-2-methylquinoline
2-Methyl-5-[2-[4-(8-quinolinylmethyl)-1-piperazinyl]ethoxy] quinoline
2-Methyl-5-(2-(4-(quinolin-8-ylmethyl)-piperazin-1-yl)ethoxy)quinoline
Quinoline, 2-Methyl-5-[2-[4-(8-quinolinylMethyl)-1-piperazinyl]ethoxy]- | [Molecular Formula]
C26H28N4O | [MDL Number]
MFCD19982820 | [MOL File]
584555-10-2.mol | [Molecular Weight]
412.53 |
| Hazard Information | Back Directory | [Uses]
SB 714786 is a potent and selective 5-hydroxytryptamine 1D (5-HT1D) receptor antagonist. It was developed from the previously reported series of dual 5-HT1 selective 5-hydroxytryptamine reuptake inhibitors (5HT1-SSRIs). SB 714786 is the first reported highly potent and selective 5-HT1D receptor antagonist, providing an extremely useful pharmacological tool for further understanding the role of 5-HT1 receptor subtypes. It has no or very low intrinsic activity against all three receptors. SB 714786 has pKi values of 6.5, 6.7, 9.1 and 6.5 for 5-HT1A, 5-HT1B, 5-HT1D and SerT receptors, respectively, showing high selectivity for 5-HT1D receptors. These properties make SB 714786 a potential tool compound for studying the function of 5-HT1D receptors and the treatment of related diseases. | [References]
[1] Discovery of the First Potent, Selective 5-Hydroxytryptamine1D Receptor Antagonist |
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| Company Name: |
Matrix Scientific
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| Tel: |
803 788-9494 All other calls |
| Website: |
www.matrixscientific.com |
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