| Identification | Back Directory | [Name]
2,6-Dichloro-3-methyl-5-nitropyridine | [CAS]
58596-88-6 | [Synonyms]
2,6-Dichloro-3-methyl-5-nitropyridine
Pyridine, 2,6-dichloro-3-Methyl-5-nitro-
2,6-Dichloro-3-methyl-5-nitropyridine ISO 9001：2015 REACH | [Molecular Formula]
C6H4Cl2N2O2 | [MDL Number]
MFCD17014968 | [MOL File]
58596-88-6.mol | [Molecular Weight]
207.01 |
| Chemical Properties | Back Directory | [Melting point ]
70-71 °C(Solv: cyclohexane (110-82-7)) | [Boiling point ]
323.5±37.0 °C(Predicted) | [density ]
1.537 | [storage temp. ]
Inert atmosphere,Room Temperature | [pka]
-5.36±0.10(Predicted) | [Appearance]
Off-white to light yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 2,6-dichloro-3-methyl-5-nitropyridine-1-oxide from 2-chloro-5-methyl-3-nitropyridine-1-oxide: 2-chloro-5-methyl-3-nitropyridine-1-oxide (4.0 g, 21.2 mmol) was suspended in phosphorus triclosan (ca. 20 mL) and the reaction was heated to reflux temperature for 3 hours. After completion of the reaction, the reaction mixture was carefully poured into preheated water and cooled to room temperature. It was extracted with ethyl acetate (3×), the organic phases were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 4.5 g of brown solid. The crude product was purified by fast column chromatography (dichloromethane as eluent and 5% ethyl acetate in heptane solution as elution system) to give 3.56 g (81% yield) of off-white solid. The product was analyzed by GC-MS (EI+) with m/z = 189 and purity >95%. | [References]
[1] Patent: WO2010/94645, 2010, A1. Location in patent: Page/Page column 26 |
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