| Identification | Back Directory | [Name]
DYCLONINE | [CAS]
586-60-7 | [Synonyms]
dyclonin
yclonine
DYCLONINE
dyclocaine
Dyclonine HCI
DYCLONINE USP/EP/BP
4'-Butoxy-β-piperidinopropiophenone
4’-butoxy-3-piperidino-propiophenon
1-(4-butoxyphenyl)-3-(1-piperidinyl)-1-propanon
1-(4-butoxyphenyl)-3-(piperidin-1-yl)propan-1-one
1-Propanone, 1-(4-butoxyphenyl)-3-(1-piperidinyl)- | [EINECS(EC#)]
1312995-182-4 | [Molecular Formula]
C18H27NO2 | [MDL Number]
MFCD00242641 | [MOL File]
586-60-7.mol | [Molecular Weight]
289.41 |
| Questions And Answer | Back Directory | [Preparation]
DYCLONINE hydrochloride of pharmaceutical grade was synthesized from p-hydroxyacetophenone and bromobutane via a two-step reaction using a phase-transfer catalyst. First, the intermediate p-butoxyacetophenone was generated using a phase-transfer catalyst, and then reacted with piperidine hydrochloride and paraformaldehyde to produce the final product. The structure of the synthesized product was confirmed by 1H-NMR and MS. The results showed that the overall yield of the reaction exceeded 90%, and the process was simple, easy to operate, and suitable for industrial production. |
| Hazard Information | Back Directory | [Originator]
Dyclone,Dow,US,1956 | [Uses]
anesthetic (local) | [Definition]
ChEBI: N-Ethylpiperidine in which one of the hydrogens attached to the methyl group is substituted by a 4-butoxybenzoyl group. | [Manufacturing Process]
A mixture of 17.6 grams of p-n-butoxyacetophenone, 12.1 grams of piperidine
hydrochloride, 4.5 grams paraformaldehyde, 0.25 cc concentrated hydrochloric
acid, 52.5 cc nitroethane, 7.5 cc of 95% ethanol, and 15 cc of toluene was
boiled under reflux for one hour, removing water formed in the reaction by
means of a condensate trap. The mixture was then cooled. The crystals which
formed were collected by filtration, washed with anhydrous ether and
recrystallized from methyl ethyl ketone. The crystals thus obtained, which
melted at 174-175°C, were shown by analysis to be 4-n-butoxy-β-
piperidinopropiophenone hydrochloride. | [Brand name]
Dyclone (AstraZeneca). | [Therapeutic Function]
Local anesthetic |
|
| Company Name: |
Shangchem Co., Ltd.
|
| Telephone: |
+86-21-68182121 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList14031/0_EN.htm |
| Company Name: |
PI & PI BIOTECH INC.
|
| Telephone: |
+86-13602409664 +86-17788709170 |
| Website: |
www.paypaytech.com/ |
|