| Identification | Back Directory | [Name]
2(1H)-Quinoxalinone,1-ethyl-3-(methylamino)-(9CI) | [CAS]
586348-21-2 | [Synonyms]
Ataquimas
2(1H)-Quinoxalinone, 1-ethyl-3-(methylamino)-
2(1H)-Quinoxalinone,1-ethyl-3-(methylamino)-(9CI) | [Molecular Formula]
C11H13N3O | [MDL Number]
MFCD18811516 | [MOL File]
586348-21-2.mol | [Molecular Weight]
203.24 |
| Chemical Properties | Back Directory | [Melting point ]
137-138 °C(Solv: ethanol (64-17-5)) | [Boiling point ]
335.8±25.0 °C(Predicted) | [density ]
1.20±0.1 g/cm3(Predicted) | [pka]
1.42±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
Ataquimast free base is a COX-2 inhibitor that inhibits the release of leukotrienes, TNF-α and GM-CSF. Ataquimast free base can be used in the study of advanced receptor-positive breast cancer[1]. | [References]
[1] Kobayashi Y, et al., Highly efficient synthesis of quinoxalinone-N-oxide via tandem nitrosation/aerobic oxidative C-N bond formation. Org Lett. 2011 Dec 2;13(23):6280-3. DOI:10.1021/ol202760c
[2] Kobayashi Y, et al. Highly efficient synthesis of quinoxalinone-N-oxide via tandem nitrosation/aerobic oxidative C-N bond formation. Org Lett. 2011 Dec 2;13(23):6280-3. DOI:10.1021/ol202760c |
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