| Identification | Back Directory | [Name]
Meclonazepam | [CAS]
58662-84-3 | [Synonyms]
Ro-11-3128
Meclonazepam
Meclonazepamum
Meclonazepam, 3-Methylclonazepam
(3S)-5-(2-chlorophenyl)-3-methyl-7-nitro-1,3-dihydro-1,4-benzodiazepin-2-one
(S)-5-(2-Chlorophenyl)-1,3-dihydro-3-methyl-7-nitro-2H-1,4-benzodiazepin-2-one
(3S)-5-(2-Chlorophenyl)-1,3-dihydro-3-methyl-7-nitro-2H-1,4-benzodiazepin-2-one
2H-1,4-Benzodiazepin-2-one, 5-(2-chlorophenyl)-1,3-dihydro-3-methyl-7-nitro-, (3S)- | [EINECS(EC#)]
200-001-8 | [Molecular Formula]
C16H12ClN3O3 | [MOL File]
58662-84-3.mol | [Molecular Weight]
329.74 |
| Chemical Properties | Back Directory | [Boiling point ]
522.1±50.0 °C(Predicted) | [density ]
1.46 | [storage temp. ]
-20°C | [solubility ]
DMF: 25 mg/ml; DMSO: 25 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Methanol: 1 mg/ml | [form ]
A crystalline solid | [pka]
11.24±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Meclonazepam-d4, is the labeled analogue of Meclonazepam (M202790), a drug of a benzodiazepine class similar in structure to Clonazepam (C587080). It has sedative and anxiolytic properties. It has also shown to have anti-parasitic effects against the parasitic worm Schistosoma mansoni. | [in vivo]
Meclonazepam (0.1-5.6 mg/kg) exhibits anxiolytic effect in gerbils[1].
Meclonazepam (40 and 80 mg/kg) Has highly significant effect on the immature schistosomes[2]. | Animal Model: | Adult experimentally naive male Mongolian gerbils (Meriones unguiculatus)[1] | | Dosage: | 0.1, 0.3, 1.0, 3.0, 5.6 mg/kg | | Administration: | Administration intraperitoneally (IP) 5 min prior to training onset. | | Result: | The ED50 of 0.77-0.78 mg/kg at the 5 min post-injection (p.i.).
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| Animal Model: | CB6F1 mice were infected with single-sex male S. mansoni cercariae 28 days before treatment[2] | | Dosage: | 40 and 80 mg/kg | | Administration: | Administered by gavage either as single drugs or in a sequence consisting of 1 dose of Praziquantel (PZQ), a 5-min interval, 1 dose of Ro, a 15-min interval, a second dose of PZQ. | | Result: | PZQ had no significant effect on the immature schistosomes, whereas Ro 11-3128 was highly effective.
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| [IC 50]
Schistosome |
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