| Identification | Back Directory | [Name]
LANTHANUM CARBONATE | [CAS]
587-26-8 | [Synonyms]
LANTHANUM CARBONATE
dilanthanum tricarbonate
LANTHANUM (III) CARBONATE
lanthanum(3+) tricarbonate
Lanthanum Carbonate powder
Carbonic acid, lanthanum(3++) salt (3:2) | [EINECS(EC#)]
209-599-5 | [Molecular Formula]
C3La2O9 | [MDL Number]
MFCD00011069 | [MOL File]
587-26-8.mol | [Molecular Weight]
457.84 |
| Hazard Information | Back Directory | [Uses]
Treatment of hyperphosphatae mia in patients with end stage renal disease. | [Brand name]
Fosrenol
(Shire). | [Flammability and Explosibility]
Notclassified | [Mechanism of action]
Lanthanum Carbonate inhibits phosphate absorption from the intestine and lowers the phosphate levels in the blood. Lanthanum Carbonate inhibits phosphate absorption from the intestine and lowers the phosphate levels in the blood.
| [Clinical Use]
#N/A | [Side effects]
Nausea, Vomiting, Abdominal pain | [in vitro]
Lanthanum carbonate is an ideal phosphate binder. It prevents the adsorption of dietary phosphate by forming insoluble lanthanum phosphate. It has been reported that lanthanum carbonate binds phosphate optimally at pH 3–5, while retaining binding activity at pH 1–7. In vitro, studies suggest that the efficacy of lanthanum phosphate is comparable to that of aluminium compounds in binding with phosphate. The FDA has approved using lanthanum carbonate as a phosphate binder for renal failure patients. | [Drug interactions]
Potentially hazardous interactions with other drugs
Antibacterials: possibly reduces absorption of
quinolones - give at least 2 hours before or 4 hours
after lanthanum.
Antifungals: absorption of ketoconazole reduced -
give at least 2 hours apart.
Antimalarials: absorption of chloroquine and
hydroxychloroquine possibly reduced - give at least
2 hours apart.
Thyroid hormones: reduces absorption of
levothyroxine - give at least 2 hours apart | [Metabolism]
Lanthanum carbonate is poorly absorbed from the
gastrointestinal tract, with an absolute oral bioavailability
of less than 1%. The small fraction that is absorbed is
more than 99% bound to plasma proteins and is widely
distributed in the tissues, particularly the bones, the
liver, and the gastrointestinal tract. Lanthanum is not
metabolised.
It is excreted mainly in the faeces with only around
0.000031% of an oral dose excreted via the urine in
healthy subjects (renal clearance approximately 1 mL/
min, representing <2% of total plasma clearance) |
|
| Company Name: |
Shanghai UCHEM Inc.
|
| Telephone: |
18939844854 |
| Website: |
www.chemicalbook.com/supplier/23967788/ |
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