| Identification | Back Directory | [Name]
N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride | [CAS]
58934-46-6 | [Synonyms]
Nsc310411
Lorcainide HCl
EINECS 261-504-6
LORCAINIDE HYDROCHLORIDE
Isocainide hydrochloride
4'-Chloro-N-(1-isopropyl-4-piperidyl)-2-phenylacetanilide monohydrochloride
N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride
N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride USP/EP/BP
Benzeneacetamide, N-(4-chlorophenyl)-N-[1-(1-methylethyl)-4-piperidinyl]-, monohydrochloride | [EINECS(EC#)]
261-504-6 | [Molecular Formula]
C22H28Cl2N2O | [MOL File]
58934-46-6.mol | [Molecular Weight]
407.377 |
| Chemical Properties | Back Directory | [Melting point ]
263° | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO (up to 20 mg/ml), in Water (up to 20 mg/ml), or in Ethanol (up to 20 mg/ml). | [form ]
White solid. | [color ]
Powder | [Water Solubility ]
H2O: 10mg/mL, clear | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO, distilled water or ethanol may be stored at -20°C for up to 1 month | [InChI]
1S/C22H27ClN2O.ClH/c1-17(2)24-14-12-21(13-15-24)25(20-10-8-19(23)9-11-20)22(26)16-18-6-4-3-5-7-18;/h3-11,17,21H,12-16H2,1-2H3;1H | [InChIKey]
FSFSWNBDCJVFGI-UHFFFAOYSA-N | [SMILES]
Clc1ccc(cc1)N(C3CCN(CC3)C(C)C)C(=O)Cc2ccccc2.Cl |
| Hazard Information | Back Directory | [Description]
Lorcainide hydrochloride (58934-46-6) is a voltage-gated Na+?channel blocker.1?Protects murine cultured cortical neurons from injury induced by oxygen-glucose deprivation.2?Acts at the ouabain binding site of guinea pig cardiac Na+/K+?ATPase and inhibits the enzyme (IC50?= 34 μM).3 | [Uses]
Cardiac depressant (anti-arrhythmic). | [References]
1) Sheldon?et al.?(1989),?Antiarrhythmic drugs and the cardiac sodium channel: current models; Clin. Chem.,?35?748
2) Lynch?et al.?(1995),?Sodium channel clockers reduce oxygen-glucose deprivation-induced cortical neuronal injury when combined with glutamate receptor antagonists; J. Pharmacol. Exp. Ther.,?273?554
3) Almotrefi?et al. (1999),?Class I antiarrhythmic drug effects on ouabain binding to guinea pig cardiac Na+ -K+ ATPase; Can. J. Physiol. Pharmacol.,?77?866 |
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