| Identification | Back Directory | [Name]
2-amino-4-chlorobenzamide | [CAS]
5900-59-4 | [Synonyms]
4-Chloroanthranilamide
2-aMino-4-chlrobenzaMide
2-amino-4-chlorobenzamide
Benzamide, 2-amino-4-chloro-
2-amino-4-chlorophenylformamide
2-amino-4-chlorobenzamide(SALTDATA: FREE) | [EINECS(EC#)]
200-002-4 | [Molecular Formula]
C7H7ClN2O | [MDL Number]
MFCD09042792 | [MOL File]
5900-59-4.mol | [Molecular Weight]
170.6 |
| Chemical Properties | Back Directory | [Melting point ]
181.5 °C | [Boiling point ]
308.8±27.0 °C(Predicted) | [density ]
1.394±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [form ]
solid | [pka]
15.48±0.50(Predicted) | [Appearance]
Off-white to light yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
Method I: Synthesis of 2-amino-4-chlorobenzamide (ii-b)
1. 2-Amino-4-chlorobenzoic acid (3.42 g, 20 mmol) was dissolved in DMF (45 mL) and HOBt (2.70 g, 20 mmol) was added.
2. After stirring for 10 min, EDC-HCl (3.82 g, 20 mmol) was added to the mixture.
3. the reaction mixture was stirred at room temperature for 2 hr.
4. NH4OH (28%, 5 mL) was slowly added at 0 °C with vigorous stirring.
5. After addition, continue stirring at room temperature for 2 hours.
6. The reaction mixture was added slowly dropwise to water (200 mL) and a precipitate was precipitated.
7. The precipitate was collected by filtration and dried under vacuum to give 2.98 g of the target product ii-b as a gray solid in 87.6% yield. 8.
8. The product was characterized by LCMS m/z = 171.0 (M + 1), 173.0 (M + 3) (Method B) (retention time = 1.39 min).
1H NMR (400 MHz, DMSO-d6): δ 7.27 (d, J = 9.6 Hz, 1H), 6.68 (d, J = 2.4 Hz, 1H), 6.60 (dd, J = 8.4, 2.0 Hz, 1H), 5.50-5.82 (m, 4H). | [References]
[1] European Journal of Medicinal Chemistry, 2018, vol. 157, p. 1361 - 1375
[2] Patent: US2015/307477, 2015, A1. Location in patent: Paragraph 1473
[3] Patent: JP6121658, 2017, B2. Location in patent: Paragraph 1063; 1064; 1065
[4] Patent: WO2010/99379, 2010, A1. Location in patent: Page/Page column 142
[5] Arkivoc, 2012, vol. 2012, # 8, p. 198 - 213 |
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