| Identification | Back Directory | [Name]
WX-671/Mesupron | [CAS]
590368-25-5 | [Synonyms]
WX-671
UPAMOSTAT
WX-671/Mesupron
Mesupron(WX 671)
Mesupron（Upamostat）
HUASEDVYRABWCV-NDEPHWFRSA-N
4-[(2S)-3-[3-[(Hydroxyamino)iminomethyl]phenyl]-1-oxo-2-[[[2,4,6-tris(1-methylethyl)phenyl]sulfonyl]amino]propyl]-1-piperazinecarboxylic acid ethyl ester
1-Piperazinecarboxylic acid, 4-[(2S)-3-[3-[(hydroxyamino)iminomethyl]phenyl]-1-oxo-2-[[[2,4,6-tris(1-methylethyl)phenyl]sulfonyl]amino]propyl]-, ethyl ester | [Molecular Formula]
C32H47N5O6S | [MDL Number]
MFCD20526529 | [MOL File]
590368-25-5.mol | [Molecular Weight]
629.81 |
| Chemical Properties | Back Directory | [Boiling point ]
761.3±70.0 °C(Predicted) | [density ]
1.25 | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 250 mg/mL (396.95 mM) | [form ]
Solid | [pka]
6.99±0.69(Predicted) | [color ]
White to off-white | [InChIKey]
CYCFEEXTLQGJEL-LJAQVGFWSA-N | [SMILES]
N1(C(OCC)=O)CCN(C(=O)[C@@H](NS(C2=C(C(C)C)C=C(C(C)C)C=C2C(C)C)(=O)=O)CC2=CC=CC(C=NNO)=C2)CC1 |
| Hazard Information | Back Directory | [Uses]
WX 671 is the oral pro-drug of the active metabolite WX-UK1, a uPA inhibitor. | [in vivo]
The validated method is used to evaluate the pharmacokinetics of Upamostat (Mesupron) in rats. The mean plasma concentrations of Upamostat after a single intravenous injection of 2 mg/kg in five rats are measured. The substance decays in a mono-phasic pattern with a terminal half-life of 0.5 h; its volume of distribution is 2.0 L/kg, and clearance is about 2.7 L/h/kg[3]. | [storage]
Store at -20°C |
|
| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
Alabiotech Inc.
|
| Tel: |
001-619-354-5251 |
| Website: |
www.alabiotech-e.com |
|