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591230-99-8

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591230-99-8 Structure

591230-99-8 Structure
IdentificationBack Directory
[Name]

DisodiuM trans-crocetinate
[CAS]

591230-99-8
[Synonyms]

Transcrocetinate sodium
Transcrocetinate disodium
DisodiuM trans-crocetinate
Trans Sodium Crocetinate( Disodium trans-crocetinate)
Transcrocetinate disodium (Disodium trans-crocetinate)
Transcrocetinate disodium (Synonyms: Disodium trans-crocetinate)
[Molecular Formula]

C20H25NaO4
[MOL File]

591230-99-8.mol
[Molecular Weight]

352.41
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

H2O:16.67(Max Conc. mg/mL);44.77(Max Conc. mM)
[form ]

Solid
[color ]

Brown to reddish brown
Hazard InformationBack Directory
[Uses]

Crocetin (Transcrocetin) disodium, extracted from saffron (Crocus sativus L.), acts as an NMDA receptor antagonist with high affinity.
[Biological Activity]

DisodiuM trans-crocetinate, extracted from saffron (Crocus sativus L.), is a high-affinity NMDA receptor antagonist.
[in vitro]

Transcrocetinate (Transcrocetin, trans-Crocetin), a saffron metabolite originating from the crocin apocarotenoids, has been shown to exert strong NMDA receptor affinity and is thought to be responsible for the CNS activity of saffron. To ensure unchanged viability of Caco-2 cells throughout the transport experiments, cellular mitochondrial dehydrogenase activity of Caco-2 cells is measured by MTT assay after a 24 h incubation period with the test compounds: Hydroalcoholic saffron extract saffron extract (SE, 0.5-1 mg/mL) and crocin-1 (250-1000 μM) reveal no negative significant changes in cellular viability. Transcrocetinate at 10 μM level does not change viability while higher concentrations (40-160 μM) reduces significantly cellular viability.

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[target]

NMDA receptor

[IC 50]

NMDA Receptor
[storage]

Store at -20°C
[References]

[1] Lautenschl?ger M, et al. Intestinal formation of trans-Crocetin from saffron extract (Crocus sativus L.) and in vitro permeation through intestinal and blood brain barrier. Phytomedicine. 2015 Jan 15;22(1):36-44. DOI:10.1016/j.phymed.2014.10.009
Spectrum DetailBack Directory
[Spectrum Detail]

DisodiuM trans-crocetinate(591230-99-8)1HNMR
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