| Identification | Back Directory | [Name]
Di(N-succinimidyl) adipate | [CAS]
59156-70-6 | [Synonyms]
RG 00/265
Di(N-succinimidyl) adipate
Bis-N-Hydroxysuccinimidyl adipate
bis(2,5-dioxopyrrolidin-1-yl) adipate
bis(2,5-dioxopyrrolidin-1-yl) hexanedioate
Adipic acid bis-(N-hydroxysuccinimide) ester
Hexanedioic acid 1,6-bis(2,5-dioxo-1-pyrrolidinyl) ester
2,5-Pyrrolidinedione, 1,1'-[(1,6-dioxo-1,6-hexanediyl)bis(oxy)]bis- | [Molecular Formula]
C14H16N2O8 | [MDL Number]
MFCD01318516 | [MOL File]
59156-70-6.mol | [Molecular Weight]
340.29 |
| Chemical Properties | Back Directory | [Melting point ]
163-164℃ (ethanol acetonitrile ) | [Boiling point ]
495.3±55.0 °C(Predicted) | [density ]
1.48±0.1 g/cm3 (20 ºC 760 Torr) | [solubility ]
Soluble in DMSO, DMF, Acetonitrile | [form ]
Solid | [color ]
White to off-white | [InChI]
InChI=1S/C14H16N2O8/c17-9-5-6-10(18)15(9)23-13(21)3-1-2-4-14(22)24-16-11(19)7-8-12(16)20/h1-8H2 | [InChIKey]
LZZXZDMVRZJZST-UHFFFAOYSA-N | [SMILES]
C(ON1C(=O)CCC1=O)(=O)CCCCC(ON1C(=O)CCC1=O)=O |
| Hazard Information | Back Directory | [Description]
Di(N-succinimidyl)adipate contains two NHS ester groups which can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. | [Uses]
Di(N-succinimidyl)adipate is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
Alkyl-Chain | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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