| Identification | Back Directory | [Name]
neothramycin A | [CAS]
59593-16-7 | [Synonyms]
neothramycin A
(3S)-1,2,3,11aβ-Tetrahydro-3,8-dihydroxy-7-methoxy-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one
5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one, 1,2,3,11a-tetrahydro-3,8-dihydroxy-7-methoxy-, (3S,11aS)- | [Molecular Formula]
C13H14N2O4 | [MOL File]
59593-16-7.mol | [Molecular Weight]
262.26 |
| Hazard Information | Back Directory | [Description]
Neothramycin A is a pyrrol[1,4]benzodiazepine antibiotic. | [Uses]
Neothramycin A is an antibiotic, which can be isolated from Streptomyces. Neothramycin A exhibits board spectrum antimicrobial activity, inhibits Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli W677, and Saccharomyces cerevisia with MIC of 25-50 μg/mL. Neothramycin A exhibits antitumor efficacy against leukemia in mouse models[1]. | [References]
[1] Takeuchi T, et al., Neothramycins A and B, new antitumor antibiotics. J Antibiot (Tokyo). 1976 Jan;29(1):93-6. DOI:10.7164/antibiotics.29.93 |
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