59702-07-7

110-85-0

59702-07-7

The general procedure for the synthesis of 1-methylpiperazin-2-one using piperazine as starting material was as follows: piperazine was dissolved in 70 mL of a 50% aqueous acetone solution containing 2.2 g of sodium hydroxide, and the resulting solution was stirred and reacted for 3 hours at room temperature. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was added to acetone to precipitate insoluble impurities. The insoluble material was separated by filtration and the filtrate was removed from the acetone by distillation under reduced pressure. Finally, the residue was distilled under reduced pressure to give 5.2 g of 1-methylpiperazin-2-one with a boiling point of 104°C/4 mmHg in 91% yield.