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59865-15-5

59865-15-5 Structure

59865-15-5 Structure
IdentificationBack Directory
[Name]

DIHYDROCYCLOSPORIN A
[CAS]

59865-15-5
[Synonyms]

CS-2523
59865-15-5
Capecitabine Imp.G
Dihydrocyclosporin
DIHYDROCYCLOSPORIN A
Dihydrocyclosporine A
Cyclosporin Impurity 10
Cyclosporine Impurity 10
Cyclosporin A Dihydro IMpurity
Dihydrocyclosporin A reference
Cyclosporin Impurity 10(Dihydrocyclosporin A)
6-[(2S,3R,4R)-3-Hydroxy-4-Methyl-2-(MethylaMino)octanoic acid]cyclosporin A
Cyclosporin A,6-[(2S,3R,4R)-3-hydroxy-4-methyl-2-(methylamino)octanoic acid]-
Dihydrocyclosporine A/6-[(2S,3R,4R)-3-Hydroxy-4-methyl-2-(methylamino)octanoic acid]cyclosporin A
(3R,4R)-3-Hydroxy-N-methyl-5-propylcyclo(L-Leu-L-Abu-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-)
(3R,4R)-3-Hydroxy-4,N-dimethyl-5-propylcyclo[L-Nva-L-Abu-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-]
[Molecular Formula]

C62H113N11O12
[MDL Number]

MFCD08458303
[MOL File]

59865-15-5.mol
[Molecular Weight]

1204.63
Chemical PropertiesBack Directory
[Melting point ]

120-125?C
[Boiling point ]

1285.3±65.0 °C(Predicted)
[density ]

1.012±0.06 g/cm3(Predicted)
[storage temp. ]

Refrigerator
[solubility ]

Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
[form ]

Solid
[pka]

13.33±0.70(Predicted)
[color ]

White
[InChIKey]

TYFOVYYNQGNDKH-AAJDKDKZNA-N
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)Health Hazard (GHS08)
GHS07,GHS08
[Signal word ]

Danger
[Hazard statements ]

H350-H302-H362
[Precautionary statements ]

P264-P270-P301+P312-P330-P501-P201-P260-P263-P264-P270-P308+P313
Hazard InformationBack Directory
[Chemical Properties]

White Solid
[Uses]

A Cyclosporin A (C988900) analog, an immunosuppressant.
[Uses]

Dihydrocyclosporin A is a closely related co-metabolite of cyclosporin A. Dihydrocyclosporin A possesses no immunosuppressant activity and has found use as a control to determine the role of immunosuppression in the pharmacology of cyclosporin A, particularly in the treatment of parasitic infections.
[Side effects]

Dihydrocyclosporine A has no obvious nephrotoxic effect, but it exhibits hepatotoxic effects, often leading to hypertension.
Spectrum DetailBack Directory
[Spectrum Detail]

DIHYDROCYCLOSPORIN A(59865-15-5)1HNMR
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