| Identification | Back Directory | [Name]
13,14-DIHYDRO-15-KETO PROSTAGLANDIN D2 | [CAS]
59894-07-4 | [Synonyms]
DK-PGD2
13,14-Dihydro-15-keto-PGD2
13,14-Dihydro-15-ketoprostadlandin D2
13,14-DIHYDRO-15-KETO PROSTAGLANDIN D2
9ALPHA-HYDROXY-11,15-DIOXO-PROST-5Z-EN-1-OIC ACID
13,14-dihydro-15-keto Prostaglandin D2
(5Z,9α)-9-Hydroxy-11,15-dioxoprost-5-en-1-oic acid
13,14-dihydro-15-keto Prostaglandin D2 MaxSpecStandard
13,14-dihydro-15-keto Prostaglandin D2 Lipid Maps MS Standard | [Molecular Formula]
C20H32O5 | [MDL Number]
MFCD00885499 | [MOL File]
59894-07-4.mol | [Molecular Weight]
352.47 |
| Chemical Properties | Back Directory | [Boiling point ]
542.1±40.0 °C(Predicted) | [density ]
1.086±0.06 g/cm3(Predicted) | [solubility ]
DMF: 50 mg/ml
DMSO: 30 mg/ml
Ethanol: 50 mg/mlPBS pH 7.2: 2.5 mg/ml | [pka]
4.76±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
13,14-dihydro-15-keto Prostaglandin D2 (13,14-dihydro-15-keto PGD2) is a metabolite of PGD2 which is formed through the 15-hydroxy PGDH pathway. 13,14-dihydro-15-keto PGD2 was recently identified as a selective agonist for the CRTH2/DP2 receptor. It also inhibits ion flux in a canine colonic mucosa preparation. In humans, 13,14-dihydro-15-keto PGD2 is further metabolized to give 11β-hydroxy compounds which have also undergone β-oxidation of one or both side chains. Virtually no 13,14-dihydro-15-keto PGD2 survives intact in the urine. | [Uses]
13,14-Dihydro-15-keto-PGD2 is a metabolite of Prostaglandin D2 (CAT# P838575) and a selective CRTh2/DP2 receptor agonist. CRTh2/DP2 receptors play crucial roles in atopic dermatitis, asthma, and other inflammatory diseases. | [Definition]
ChEBI: 13,14-dihydro-15-ketoprostaglandin D2 is a prostaglandins D. It has a role as a metabolite. It is functionally related to a prostaglandin D2. | [References]
[1] P K RANGACHARI P A B. Biological activity of metabolites of PGD2 on canine proximal colon.[J]. American Journal of Physiology, 1993, 264 5 Pt 1: G886-94. DOI: 10.1152/ajpgi.1993.264.5.g886
[2] H. HIRAI. Prostaglandin D2 Selectively Induces Chemotaxis in T Helper Type 2 Cells, Eosinophils, and Basophils via Seven-Transmembrane Receptor Crth2[J]. The Tokushima journal of experimental medicine, 2001, 1 1: 255-262. DOI: 10.1084/jem.193.2.255
[3] T E LISTON L J R. Metabolic fate of radiolabeled prostaglandin D2 in a normal human male volunteer.[J]. The Journal of Biological Chemistry, 1985, 260 24: 13172-13180.
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