| Identification | Back Directory | [Name]
NSC-249918 | [CAS]
60066-35-5 | [Synonyms]
NSC-249918
Goyazensolide
2-Methylpropenoic acid [(3aR,4S,6R,10Z,11aR)-2,3,3a,4,5,6,7,11a-octahydro-10-hydroxymethyl-6-methyl-3-methylene-2,7-dioxo-6,9-epoxycyclodeca[b]furan-4-yl] ester
2-Propenoic acid, 2-methyl-, (3aR,4S,6R,10Z,11aR)-2,3,3a,4,5,6,7,11a-octahydro-10-(hydroxymethyl)-6-methyl-3-methylene-2,7-dioxo-6,9-epoxycyclodeca[b]furan-4-yl ester | [Molecular Formula]
C19H20O7 | [MOL File]
60066-35-5.mol | [Molecular Weight]
360.36 |
| Hazard Information | Back Directory | [Uses]
Goyazensolide is an inhibitor of NF-κB that can induce apoptosis in cancer cells and exhibits both anti-inflammatory and anticancer activities. Goyazensolide is a sesquiterpene lactone that can be found in the Argentine herb Centratherum punctatum[1][2][3]. | [References]
[1] Pierre Alexandre dos Santos, et al. Production of an antiproliferative furanoheliangolide by Lychnophora ericoides cell culture. Chem Pharm Bull (Tokyo). 2004 Dec;52(12):1433-5. DOI:10.1248/cpb.52.1433
[2] Susana Amaya, et al. Inhibition of quorum sensing in Pseudomonas aeruginosa by sesquiterpene lactones. Phytomedicine. 2012 Oct 15;19(13):1173-7. DOI:10.1016/j.phymed.2012.07.003
[3] Acu?a UM, et al. Goyazensolide Induces Apoptosis in Cancer Cells in vitro and in vivo. Int J Cancer Res. 2013;9(2):36-53. DOI:10.3923/ijcr.2013.36.53 |
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