| Identification | Back Directory | [Name]
LEU-ENKEPHALIN AMIDE | [CAS]
60117-24-0 | [Synonyms]
YGGFL-NH2
NSC 351912
LEU-ENKEPHALIN NH2
enkephalinamide-leu
LEU-ENKEPHALIN AMIDE
[LEU5]-ENKEPHALIN AMIDE
DYNORPHIN A (1-5) AMIDE
TYR-GLY-GLY-PHE-LEU-NH2
leucine enkephalinamide
H-TYR-GLY-GLY-PHE-LEU-NH2
L-Tyr-Gly-Gly-L-Phe-L-Leu-NH2
ALPHA-NEOENDORPHIN (1-5) AMIDE
leucine enkephalinamide acetate
Leu-Enkephalin amide acetate salt
4-Hydroxy-L-Phe-Gly-Gly-Phe-Leu-NH2
DYNORPHIN A (1-5) AMIDE ACETATE SALT
H-TYR-GLY-GLY-PHE-LEU-NH2 ACETATE SALT
Leu-Enkephalin amide,α-Neoendorphin (1-5) amide
a-Neoendorphin (1-5) aMide, Dynorphin A (1-5) aMide
L-Leucinamide, L-tyrosylglycylglycyl-L-phenylalanyl-
Leu-Enkephalin amide acetate salt H-Tyr-Gly-Gly-Phe-Leu-NH2 acetate salt | [Molecular Formula]
C28H38N6O6 | [MDL Number]
MFCD00076407 | [MOL File]
60117-24-0.mol | [Molecular Weight]
554.64 |
| Chemical Properties | Back Directory | [Melting point ]
123-126 °C | [Boiling point ]
1012.8±65.0 °C(Predicted) | [density ]
1.254±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
9.97±0.15(Predicted) | [color ]
White to off-white | [Sequence]
Tyr-Gly-Gly-Phe-Leu-NH2 |
| Hazard Information | Back Directory | [Uses]
[Leu5]-Enkephalin, amide is a δ opioid receptor agonist. | [in vivo]
Levels of [Leu5]-Enkephalin are significantly increased in the nucleus raphe magnus (NRM) of rats 2 weeks after the injection of complete Freund's adjuvant (CFA) (1.02±0.2 pmol/mg protein) as compared with saline-treated rats (0.49±0.04 pmol/mg protein; p<0.01). Tissue levels of [Leu5]-Enkephalin are uniformly increased in the caudal ventrolateral periaqueductal gray (PAG) 4 hr (1.15±0.25 pmol/mg protein), 4 d (1.16±0.18 pmol/mg protein), and 2 weeks (1.18±0.17 pmol/mg protein) after the injection of CFA as compared with saline-treated rats (0.55±0.03 pmol/mg protein; p<0.05, all times). A smaller increase in the levels of [Leu5]-Enkephalin occurred in the rostral aspect of the ventrolateral PAG at all time points. Finally, levels of [Leu5]-Enkephalin are also increased in the contralateral microcellular tegmental nucleus 4 d after the injection of CFA (0.53±0.04 pmol/mg protein) compared with levels in saline-treated rats (0.38±0.02 pmol/mg protein; p<0.05)[1]. | [References]
[1] Hurley RW, et al. Contribution of endogenous enkephalins to the enhanced analgesic effects of supraspinal mu opioid receptor agonists after inflammatory injury. J Neurosci. 2001 Apr 1;21(7):2536-45. DOI:10.1523/JNEUROSCI.21-07-02536.2001
[2] Kennedy C, et al. [Met5]enkephalin acts via delta-opioid receptors to inhibit pelvic nerve-evoked contractions of cat distal colon. Br J Pharmacol. 1987 Oct;92(2):291-8. DOI:10.1111/j.1476-5381.1987.tb11323.x |
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