| Identification | Back Directory | [Name]
GABAPENTIN-D6 HYDROCHLORIDE | [CAS]
60142-95-2 | [Synonyms]
Neurontin HCl
Neurontin hydrochloride
GABAPENTIN-D6 HYDROCHLORIDE
GABAPENTIN-D6 HYDROCHLORIDE USP/EP/BP
1-AMINOMETHYL CYCLOHEXANACTIC ACID HYDROCHLORIDE
1-(aminomethyl)cyclohexaneacetic acid hydrochloride
2-(1-(aminomethyl)cyclohexyl)acetic acid hydrochloride
Cyclohexaneacetic acid, 1-(aminomethyl)-, hydrochloride (1:1)
1-(Amino Methyl) Cyclohexane Acetic Acid Hydrochloride
Hemihydrate Salt | [EINECS(EC#)]
262-075-8 | [Molecular Formula]
C9H12ClD6NO2 | [MDL Number]
MFCD08063446 | [MOL File]
60142-95-2.mol | [Molecular Weight]
213.73 |
| Chemical Properties | Back Directory | [Melting point ]
148-151℃ (ethanol ) | [density ]
0.001g/cm3 at 20℃ | [storage temp. ]
Refrigerator | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White | [LogP]
-1.33--1.17 at pH4-9 | [Surface tension]
63.69mN/m at 1g/L and 20℃ |
| Hazard Information | Back Directory | [Uses]
Gabapentin Hydrochloride is a salt analogue of Gabapentin-d6 (G117253), a labelled amino acid structurally related to γ-Aminobutyric Acid (GABA), designed to cross the blood brain barrier. Used as an anticonvulsant. | [Biological Activity]
gabapentin (neurontin) is a pharmaceutical drug, specifically a gaba analog. it was originally developed to treatepilepsy, and currently is also used to relieve neuropathic pain. | [in vivo]
Gabapentin (5 and 10 mg/kg; i.p.; once; male BALB/c mice) hydrochloride has improving effects on spatial and emotional cognitive performance of naive mice in Morris water maze (MWM), passive avoidance (PA) and modified elevated plus maze (mEPM) tasks[2].
Gabapentin (1-100 mg/kg; i.p.; once; male mice) hydrochloride has analgesic effect and reduces writhing in a dose-dependent manner[3].
| Animal Model: | Male BALB/c mice (35-45 g)[2] | | Dosage: | 5 and 10 mg/kg | | Administration: | Intraperitoneal injection; once | | Result: | Increased the time spent in target quadrant and decreased the distance to platform in MWM test
.
Decreased the transfer latency on second day in mEPM test
.
Prolonged retention latency in PA test
.
|
| Animal Model: | Male mice (26-30 g)[3] | | Dosage: | 1, 5, 10, 50 and 100 mg/kg | | Administration: | Intraperitoneal injection; once | | Result: | Produced 45-70% inhibition of writhing. |
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| Company Name: |
PI & PI BIOTECH INC.
|
| Telephone: |
+86-13602409664 +86-17788709170 |
| Website: |
www.paypaytech.com/ |
| Company Name: |
AFINE CHEMICALS LIMITED
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| Telephone: |
+86-571-85134551 +86-18958018566 |
| Website: |
www.afinechem.com/index.html |
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