| Identification | Back Directory | [Name]
4-BROMO-2,6-DIMETHOXY-PYRIMIDINE | [CAS]
60186-89-2 | [Synonyms]
6-Bromo-2,4-dimethoxypyrimidine
4-BROMO-2,6-DIMETHOXY-PYRIMIDINE
Pyrimidine, 4-bromo-2,6-dimethoxy-
4-BROMO-2,6-DIMETHOXY-PYRIMIDINE ISO 9001：2015 REACH | [Molecular Formula]
C6H7BrN2O2 | [MDL Number]
MFCD07787454 | [MOL File]
60186-89-2.mol | [Molecular Weight]
219.04 |
| Chemical Properties | Back Directory | [Boiling point ]
294.7±43.0 °C(Predicted) | [density ]
1.563±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [pka]
-1.75±0.30(Predicted) | [Appearance]
White to light yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
To a 2L three-necked round-bottomed flask was added 2,4,6-tribromopyrimidine (54 g, 170.47 mmol, 1 eq.), methanol (500 mL), ethyl ether (500 mL), and a methanolic solution of sodium methanolate (30%, 76.7 g, 2.50 eq.), dropwise. The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the mixture was concentrated in vacuum. The concentrate was diluted with 1 L of ethyl acetate and the organic layer was subsequently washed with 3 x 500 mL of saturated sodium chloride solution. The organic layer was again concentrated in vacuum. The residue was purified by silica gel column chromatography with ethyl acetate/petroleum ether (1:100 to 1:10) as eluent. The fractions containing the target product were combined and concentrated in vacuo to afford 23 g (62% yield) of 4-bromo-2,6-dimethoxypyrimidine as a white solid. The product was confirmed by LC-MS analysis: (ES, m/z): RT = 1.287 min, LCMS 28: m/z = 219 [M + 1]. | [References]
[1] Patent: WO2017/181177, 2017, A1. Location in patent: Paragraph 01122; 01125-01127 |
|
| Company Name: |
NovoChemy Ltd.
|
| Telephone: |
86-(0)21-31261262 373522135 |
| Website: |
www.novochemy.com |
| Company Name: |
Cool Pharm, Ltd
|
| Telephone: |
021-58581007 18019463053 |
| Website: |
http://www.coolpharm.com.cn |
|