| Identification | Back Directory | [Name]
HARMALOL HYDROCHLORIDE DIHYDRATE | [CAS]
6028-00-8 | [Synonyms]
HARMALOL HYDROCHLORID DIHYDRAT
HARMALOL HYDROCHLORIDE DIHYDRATE
HARMALOL HYDROCHLORIDE HYDRATE 98%
Harmalol dihydrate hydrochloride
Harmalol hydrochloride hydrate,98%
1-Methyl-4,9-dihydro-(3H)-beta-carbolin-7-olHCl
4,9-Dihydro-1-methyl-3H-pyrido[3,4-b]indol-7-ol
4,9-DIHYDRO-1-METHYL-3H-PYRIDO[3,4-B]INDOL-7-OL DIHYDRATE
1-METHYL-7-HYDROXY-3,4-DIHYDRO-BETA-CARBOLINE HYDROCHLORIDE DIHYDRATE | [EINECS(EC#)]
227-898-9 | [Molecular Formula]
C12 H12 N2 O . H Cl . H2 O | [MDL Number]
MFCD00150053 | [MOL File]
6028-00-8.mol | [Molecular Weight]
254.72 |
| Chemical Properties | Back Directory | [Appearance]
yellow crystalline powder | [Melting point ]
265-268 °C (dec.)
| [storage temp. ]
Refrigerator (+4°C) | [solubility ]
DMF:10.0(Max Conc. mg/mL);36.67(Max Conc. mM)
DMSO:1.0(Max Conc. mg/mL);3.67(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);7.33(Max Conc. mM) | [form ]
A solid |
| Hazard Information | Back Directory | [Chemical Properties]
yellow crystalline powder | [Description]
Harmalol is a β-carboline alkaloid and an active metabolite of harmaline that has been found in P. harmala and has diverse biological activities.1,2,3,4,5 It is an inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A; IC50 = 0.63 µM) and monoamine oxidase A (MAO-A; IC50 = 0.66 µM).3 It is selective for DYRK1A over Cdk1, Cdk5, CK1α1, Clk4, DYRK2, Pim-1, and GSK3β but also inhibits DYRK1B and Clk1 at 10 µM. It inhibits proliferation of H4 human glioblastoma cells (IC50s = 23.7 µM). Harmalol (0.5-12.5 µM) reduces increases in the levels of the cytochrome P450 (CYP) isoform CYP1A1 induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells and prevents TCDD-induced activation of the aryl hydrocarbon receptor (AhR) in guinea pig hepatic cytosolic extracts.4 It reduces glutamate-induced cytotoxicity, cytochrome c release, caspase-3 activation, and the production of reactive oxygen species (ROS) in PC12 cells when used at a concentration of 25 µM.5 This product is also available as an analytical reference standard (Item No. 35145).WARNING This product is not for human or veterinary use. |
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Carbosynth
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+86 512 6260 5585 |
| Website: |
www.carbosynth.com |
| Company Name: |
Acros Organics
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+32 14/57.52.11 |
| Website: |
www.acros.be |
| Company Name: |
Leancare Ltd.
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+33 962096793 |
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www.leancare.co.uk |
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