| Identification | Back Directory | [Name]
Spiro[furan-2(5H),9'-[9H]imidazo[1,2-a]indole]-3',5(2'H)-dione, 4-[2-[(1S)-1-(acetyloxy)-2-methylpropyl]-4-oxo-3(4H)-quinazolinyl]-1',3,4,9'a-tetrahydro-1'-hydroxy-2'-methyl-, (2S,2'S,4R,9'aS)- | [CAS]
60676-56-4 | [Synonyms]
Tryptoquivaline D
Nortryptoquivaline
Spiro[furan-2(5H),9'-[9H]imidazo[1,2-a]indole]-3',5(2'H)-dione, 4-[2-[(1S)-1-(acetyloxy)-2-methylpropyl]-4-oxo-3(4H)-quinazolinyl]-1',3,4,9'a-tetrahydro-1'-hydroxy-2'-methyl-, (2S,2'S,4R,9'aS)- | [Molecular Formula]
C28H28N4O7 | [MDL Number]
MFCD33021596 | [MOL File]
60676-56-4.mol | [Molecular Weight]
532.54 |
| Chemical Properties | Back Directory | [Boiling point ]
790.4±70.0 °C(Predicted) | [density ]
1.52±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: Soluble
Methanol: Soluble | [form ]
A solid | [pka]
10.15±0.60(Predicted) |
| Hazard Information | Back Directory | [Description]
Tryptoquivaline D is a fungal metabolite that has been found in Neosartorya siamensis and has anticancer activity.1,2 It induces nuclear chromatin condensation, a marker of apoptosis, in HCT116 colon and HepG2 liver cancer cells when used at a concentration of 150 µM.1 Tryptoquivaline D (1-100 µM), alone or in combination with doxorubicin (Item No. 15007), reduces the viability of A549 lung cancer cells.2WARNING This product is not for human or veterinary use. | [References]
[1] M PRATA-SENA. Cytotoxic activity of Secondary Metabolites from Marine-derived Fungus Neosartorya siamensis in Human Cancer Cells.[J]. Phytotherapy Research, 2016, 30 11: 1862-1871. DOI: 10.1002/ptr.5696
[2] ALICE A. RAMOS. Can marine-derived fungus Neosartorya siamensis KUFA 0017 extract and its secondary metabolites enhance antitumor activity of doxorubicin? An in vitro survey unveils interactions against lung cancer cells[J]. Environmental Toxicology, 2019, 35 4: 507-517. DOI: 10.1002/tox.22886 |
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