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607723-33-1

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607723-33-1 Structure

607723-33-1 Structure
IdentificationBack Directory
[Name]

LOBEGLITAZONE
[Synonyms]

LOBEGLITAZONE
2,4-Thiazolidinedione, 5-[[4-[2-[[6-(4-methoxyphenoxy)-4-pyrimidinyl]methylamino]ethoxy]phenyl]methyl]-
5-[[4-[2-[[6-(4-methoxyphenoxy)pyrimidin-4-yl]-methylamino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
(5R)-5-[[4-[2-[[6-(4-methoxyphenoxy)pyrimidin-4-yl]-methylamino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
[Molecular Weight]

480.54
Chemical PropertiesBack Directory
[density ]

1.336±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

6.35±0.50(Predicted)
[color ]

White to off-white
[InChIKey]

CHHXEZSCHQVSRE-UHFFFAOYSA-N
[SMILES]

S1C(CC2=CC=C(OCCN(C3=CC(OC4=CC=C(OC)C=C4)=NC=N3)C)C=C2)C(=O)NC1=O
Hazard InformationBack Directory
[Definition]

ChEBI: Lobeglitazone is an aromatic ether.
[in vivo]

Lobeglitazone (1-10 mg/kg, po for 8 weeks) exhibits anti-atherosclerotic property in ApoE?/? mouse models[4].

Animal Model:ApoE?/? mouse aortic atherosclerosis models[4]
Dosage:1-10 mg/kg
Administration:po for 8 weeks
Result:Reduced aortic arch plaques.
[IC 50]

PPARγ: 137.4 nM (EC50); PPARα: 546.3 nM (EC50)
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