| Identification | Back Directory | [Name]
Acetic acid, 2-[[(2E)-4-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]-2-buten-1-yl]oxy]- | [CAS]
607737-00-8 | [Synonyms]
Acetic acid, 2-[[(2E)-4-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]-2-buten-1-yl]oxy]- | [Molecular Formula]
C23H26F2N2O3 | [MOL File]
607737-00-8.mol | [Molecular Weight]
416.46 |
| Hazard Information | Back Directory | [Uses]
SUN-1334H free base is an orally active inhibitor for histamine H1 receptor, with an IC50 of 20.3 nM and Ki of 9.7 nM. SUN-1334H free base inhibits histamine-induced contractions of isolated guinea-pig ileum with an IC50 of 0.198 μM. SUN-1334H free base inhibits histamine-induced bronchoconstriction in guinea pigs, histamine-induced skin wheals in beagle dogs, and ovalbumin-induced rhinitis in guinea pigs[1]. | [IC 50]
H1 Receptor: 20.3 nM (IC50); Dopamine D3 receptor: 3.43 μM (IC50); σ1: 5.46 μM (IC50); Alpha-1D adrenergic receptor: 7.76 μM (IC50) | [References]
[1] Mandhane SN, et al., Preclinical efficacy and safety pharmacology of SUN-1334H, a potent orally active antihistamine agent. Drugs R D. 2008;9(2):93-112. DOI:10.2165/00126839-200809020-00004 |
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