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607737-87-1

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607737-87-1 Structure

607737-87-1 Structure
IdentificationBack Directory
[Name]

4-[3-(6-METHYL-2-PYRIDINYL)-1H-PYRAZOL-4-YL]-QUINOLINE
[CAS]

607737-87-1
[Synonyms]

A77-01
A 77-01
A-77-01
CS-1775
A7701;A 7701; A-7701
4-[3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl]quinoline
4-[3-(6-METHYL-2-PYRIDINYL)-1H-PYRAZOL-4-YL]-QUINOLINE
4-[5-(6-methylpyridin-2-yl)-1~{H}-pyrazol-4-yl]quinoline
Quinoline, 4-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-
4-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]quinoline A 77-01
[Molecular Formula]

C18H14N4
[MDL Number]

MFCD07367791
[MOL File]

607737-87-1.mol
[Molecular Weight]

286.33
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

insoluble in H2O; ≥14.3 mg/mL in DMSO; ≥8.84 mg/mL in EtOH with gentle warming and ultrasonic
[form ]

solid
[color ]

Off-white to light yellow
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P280-P301+P312-P302+P352-P305+P351+P338
Hazard InformationBack Directory
[Uses]

A 77-01 is a potent inhibitor of transforming growth factor (TGF)-β type I receptor superfamily activin-like kinase ALK5 with an IC50 of 25 nM[1].
[storage]

Store at +4°C
[References]

[1] Tojo M, et al. The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. Cancer Sci. 2005 Nov;96(11):791-800. DOI:10.1111/j.1349-7006.2005.00103.x
Spectrum DetailBack Directory
[Spectrum Detail]

4-[3-(6-METHYL-2-PYRIDINYL)-1H-PYRAZOL-4-YL]-QUINOLINE(607737-87-1)1HNMR
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