| Identification | Back Directory | [Name]
(3-METHOXYBENZYL)PHOSPHONIC ACID DIETHYL ESTER | [CAS]
60815-18-1 | [Synonyms]
Diethyl 3-methoxyben
3-(DIETHYLPHOSPHONOMETHYL)ANISOLE
DIETHYL (3-METHOXYBENZYL)PHOSPHONATE
Diethyl 3-Methoxybenzyl phosphonate, 98 %
m-Methoxybenzylphosphonic acid diethyl ester
diethyl [(3-Methoxyphenyl)Methyl]phosphonate
(3-METHOXYBENZYL)PHOSPHONIC ACID DIETHYL ESTER
3-(Diethylphosphonomethyl)anisole
(3-Methoxybenzyl)phosphonic Acid Diethyl Ester | [Molecular Formula]
C12H19O4P | [MDL Number]
MFCD08276363 | [MOL File]
60815-18-1.mol | [Molecular Weight]
258.25 |
| Chemical Properties | Back Directory | [Boiling point ]
135 °C / 0.5mmHg | [density ]
1.13 | [refractive index ]
1.5020-1.5060 | [storage temp. ]
Hygroscopic, Refrigerator, under inert atmosphere | [solubility ]
Chloroform (Sparingly) | [form ]
Oil | [color ]
Colourless | [Stability:]
Moisture Sensitive | [CAS DataBase Reference]
60815-18-1 |
| Hazard Information | Back Directory | [Synthesis]
Step 1: A mixture of triethyl phosphite (1.45 g, 8.70 mmol) and 1-(bromomethyl)-3-methoxybenzene (1.50 g, 7.50 mmol) was stirred and reacted at 90 °C overnight under nitrogen protection. After completion of the reaction, the mixture was cooled to room temperature to afford the yellow oily product diethyl 3-methoxybenzylphosphonate (1.84 g, 95.9% yield). The product did not require further purification and could be used directly in the next step of the reaction. The product was characterized by the following spectral data: mass spectrum (ESI, positive ion mode) m/z: 259.2 ([M + H]+); exact mass of molecular formula C12H19O4P: 258.10. | [References]
[1] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 22, p. 7724 - 7730
[2] Patent: WO2015/90232, 2015, A1. Location in patent: Paragraph 00246
[3] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 24, p. 7444 - 7447
[4] Journal of the American Chemical Society, 1976, vol. 98, # 18, p. 5574 - 5581
[5] Journal of Medicinal Chemistry, 2005, vol. 48, # 4, p. 1292 - 1295 |
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