| Identification | Back Directory | [Name]
sultiame | [CAS]
61-56-3 | [Synonyms]
A 168
Elisal
Ospolot
Trolone
Sultiam
Canadil
Conadil
sultiame
SulthiaM
Riker 594
Contravul
Bayer A 168
SulthiaMine
SulphthiaMe
SulphenytaMe
SulphenyltaMe
4-(1,1-dioxothiazinan-2-yl)benzenesulfonamide
4-(1,1-diketothiazinan-2-yl)benzenesulfonamide
4-(1,1-dioxo-1,2-thiazinan-2-yl)benzenesulfonamide
2-(p-SulfaMoylphenyl)-tetrahydro-2H-1,2-thiazine 1,1-Dioxide
p-(Tetrahydro-2H-1,2-thiazin-2-yl)benzenesulfonaMide Dioxide
4-(Tetrahydro-1,1-dioxido-2H-1,2-thiazin-2-yl)benzenesulfonaMide
4-(Tetrahydro-2H-1,2-thiazin-2-yl)benzenesulfonaMide S,S-Dioxide
Benzenesulfonamide, 4-(tetrahydro-1,1-dioxido-2H-1,2-thiazin-2-yl)- | [EINECS(EC#)]
200-511-0 | [Molecular Formula]
C10H14N2O4S2 | [MDL Number]
MFCD00865304 | [MOL File]
61-56-3.mol | [Molecular Weight]
290.36 |
| Chemical Properties | Back Directory | [Melting point ]
180-182° | [Boiling point ]
520.2±60.0 °C(Predicted) | [density ]
1.472±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO: slightly; Methanol: slightly | [form ]
A solid | [pka]
9.90±0.10(Predicted) | [color ]
White to off-white | [InChI]
InChI=1S/C10H14N2O4S2/c11-18(15,16)10-5-3-9(4-6-10)12-7-1-2-8-17(12,13)14/h3-6H,1-2,7-8H2,(H2,11,15,16) | [InChIKey]
HMHVCUVYZFYAJI-UHFFFAOYSA-N | [SMILES]
C1(S(N)(=O)=O)=CC=C(N2CCCCS2(=O)=O)C=C1 |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Solid | [Uses]
Sultiame is a benzenesulfonamide derivative. Sultiame acts as an inhibitor of the enzyme carbonic anhydrase. Sulthiame is used as an anticonvulsant in the treatment of benign and symptomatic focal epilepsy.
| [Definition]
ChEBI: Sultiame is an organic molecular entity. | [Brand name]
Conadil (3M Pharmaceuticals); Trolone (3M Pharmaceuticals). | [Biological Activity]
Sulthiame is a carbonic anhydrase (CA) inhibitor (hCA Ki in nM = 374/I7/II95/IV81/VA91/VB134/VI6/VII43/IX56/XII; Ki = 630 mM/hCA III1.45 μM/mCA XIII1.54 μM/hCA XIV) with anticonvulsant efficacy in vivo. |
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