| Identification | Back Directory | [Name]
2-Hexenoic acid, 2,5-dimethyl-4-(methylamino)-, ethyl ester, hydrochloride, (2E,4S)- | [CAS]
610786-69-1 | [Synonyms]
Taltobulin intermediate-3
ethyl (E,4S)-2,5-dimethyl-4-(methylamino)hex-2-enoate
(S,E)-ethyl 2,5-dimethyl-4-(methylamino)hex-2-enoate hydrochloride
2-Hexenoic acid, 2,5-dimethyl-4-(methylamino)-, ethyl ester, hydrochloride, (2E,4S)- | [Molecular Formula]
C11H22ClNO2 | [MDL Number]
MFCD29472351 | [MOL File]
610786-69-1.mol | [Molecular Weight]
235.75 |
| Hazard Information | Back Directory | [Uses]
Taltobulin intermediate-3 is an intermediate in the synthesis of Taltobulin (HY-15584). Taltobulin is a common toxin component in ADC preparation (ADC Cytotoxin), and it is also a powerful tubulin (Microtubule/Tubulin) inhibitor. Taltobulin disrupts tubulin polymerization, induces mitotic arrest, and induces apoptosis[1]. | [References]
[1] Loganzo F, et al. HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Cancer Res. 2003 Apr 15;63(8):1838-45. PMID:12702571 |
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