| Identification | Back Directory | [Name]
Glycerol phenylbutyrate | [CAS]
611168-24-2 | [Synonyms]
Ravicti
HPN-100
Glycerol phenylbutryate
Glycerol phenylbutyrate
glyceryl tri-(4-phenylbutyrate)
Propane-1,2,3-triyl tris(4-phenylbutanoate)
BENZENEBUTANOIC ACID, 1,2,3-PROPANETRIYL ESTER
2,3-bis(4-phenylbutanoyloxy)propyl4-phenylbutanoate
Benzenebutanoic acid, 1,1',1''-(1,2,3-propanetriyl) ester | [Molecular Formula]
C33H38O6 | [MDL Number]
MFCD28016960 | [MOL File]
611168-24-2.mol | [Molecular Weight]
530.65 |
| Chemical Properties | Back Directory | [Boiling point ]
621.2±45.0 °C(Predicted) | [density ]
1.131±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:150.0(Max Conc. mg/mL);282.67(Max Conc. mM)
Ethanol:50.0(Max Conc. mg/mL);94.22(Max Conc. mM) | [form ]
Oil | [color ]
Colourless | [InChIKey]
ZSDBFLMJVAGKOU-UHFFFAOYSA-N | [SMILES]
C(OC(=O)CCCC1=CC=CC=C1)C(OC(=O)CCCC1=CC=CC=C1)COC(=O)CCCC1=CC=CC=C1 |
| Hazard Information | Back Directory | [Uses]
Tri(4-phenylbutyryl)glycerol is a drug that is currently under development for treatment of urea cyclic disorders (UCDs). It works by preventing the harmful buildup of ammonia in the body. | [Definition]
ChEBI: Glycerol phenylbutyrate is a triglyceride. | [Biological Activity]
Glycerol phenylbutyratea triacylglycerolis a prodrug of ER stress inhibitor 4-phenylbutyric acid (PBA). Glycerol phenylbutyrate is a nitrogen-binding agent approved for the chronic management of adult and pediatric patients (≥2 years of age) with urea cycle disorders (UCDs) who cannot be managed by dietary protein restriction and/or amino acid supplementation alone. | [in vivo]
Glycerol phenylbutyrate (GPB) has the potential for the treatment of hyperammonemia. Glycerol phenylbutyrate (GPB) may have therapeutic potential in additional conditions such as chronic hepatic encephalopathy or other inherited metabolic disorders[1][2]. | [IC 50]
Sigma 2 Receptor |
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| Company Name: |
Lynnchem
|
| Telephone: |
86-(0)29-85992781 17792393971 |
| Website: |
http://www.lynnchem.com/ |
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