| Identification | Back Directory | [Name]
2-allyl-1-((3,4-dimethoxyphenethyl)amino)-3-methylbenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile | [CAS]
612037-58-8 | [Synonyms]
BRD5459
(BRD 5459)
2-allyl-1-((3,4-dimethoxyphenethyl)amino)-3-methylbenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile
1-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-3-methyl-2-(prop-2-en-1-yl)pyrido[1,2-a]benzimidazole-4-carbonitrile
Pyrido[1,2-a]benzimidazole-4-carbonitrile, 1-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-3-methyl-2-(2-propen-1-yl)- | [Molecular Formula]
C26H26N4O2 | [MDL Number]
MFCD03666980 | [MOL File]
612037-58-8.mol | [Molecular Weight]
426.51 |
| Hazard Information | Back Directory | [Description]
BRD5459 is an enhancers of reactive oxygen species that are nontoxic or cause genotype-selective cell death. Elevation of reactive oxygen species (ROS) levels has been observed in many cancer cells relative to nontransformed cells, and recent reports have suggested that small-molecule enhancers of ROS may selectively kill cancer cells in various in vitro and in vivo models. | [Uses]
BRD5459 is a ROS chemical probe. BRD5459 can increase ROS, a marker of oxidative stress in cells, without causing cell death[1]. | [References]
[1] Adams DJ, et al. Discovery of small-molecule enhancers of reactive oxygen species that are nontoxic or cause genotype-selective cell death. ACS Chem Biol. 2013 May 17;8(5):923-9. DOI:10.1021/cb300653v |
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