| Identification | Back Directory | [Name]
1-Stearoyl-2-Arachidonoyl-sn-glycero-3-PE | [CAS]
61216-62-4 | [Synonyms]
1-Stearoyl-2-Arachidonoyl-sn-glycero-3-PE
5,8,11,14-Eicosatetraenoic acid, (1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-2-[(1-oxooctadecyl)oxy]ethyl ester, (5Z,8Z,11Z,14Z)- | [Molecular Formula]
C43H78NO8P | [MDL Number]
MFCD00674346 | [MOL File]
61216-62-4.mol | [Molecular Weight]
768.07 |
| Chemical Properties | Back Directory | [Boiling point ]
776.1±70.0 °C(Predicted) | [density ]
1.013±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Ethanol:PBS (pH 7.2)(1:2): 1 mg/ml; Methanol: 10 mg/ml | [form ]
Liquid | [pka]
1.17±0.50(Predicted) | [color ]
Colorless to light yellow | [InChIKey]
ANRKEHNWXKCXDB-BHFWLYLHSA-N | [SMILES]
[H][C@@](COP([O-])(OCC[NH3+])=O)(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O |
| Hazard Information | Back Directory | [Description]
1-Stearoyl-2-arachidonoyl-sn-glycero-3-PE is a naturally-occurring phospholipid that is formed via the phosphatidylserine decarboxylation pathway in mammalian cells. It has been used in the generation of giant unilamellar vesicles for use in the study of biological membranes. | [Uses]
18:0-20:4 PE maybe used in the preparation of liposomes. | [Uses]
SAPE is used in the mRNA combination therapy for treatment of cancer. | [Definition]
ChEBI: 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphoethanolamine zwitterion is a phosphatidylethanolamine 38:4 zwitterion obtained by transfer of a proton from the phosphate to the primary amino group of 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-icosatetraenoyl)-sn-glycero-3-phosphoethanolamine; major species at pH 7.3. It is a phosphatidylethanolamine 38:4 zwitterion and a 1-stearoyl-2-acyl-sn-glycero-3-phosphoethanolamine zwitterion. It is a tautomer of a 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphoethanolamine. | [References]
[1] ONNO B BLEIJERVELD. The CDP-ethanolamine pathway and phosphatidylserine decarboxylation generate different phosphatidylethanolamine molecular species.[J]. The Journal of Biological Chemistry, 2007, 282 39: 28362-28372. DOI: 10.1074/jbc.m703786200
[2] BILLERIT C, JEFFRIES G D M, ORWAR O, et al. Formation of giant unilamellar vesicles from spin-coated lipid films by localized IR heating?[J]. Soft Matter, 2012, 42: 10823-10826. DOI: 10.1039/c2sm26394g |
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