| Identification | Back Directory | [Name]
Tiopinac | [CAS]
61220-69-7 | [Synonyms]
Tiopinac
Dibenzo[b,e]thiepin-3-acetic acid, 6,11-dihydro-11-oxo- | [Molecular Formula]
C16H12O3S | [MDL Number]
MFCD00866083 | [MOL File]
61220-69-7.mol | [Molecular Weight]
284.33 |
| Chemical Properties | Back Directory | [Boiling point ]
541.3±50.0 °C(Predicted) | [density ]
1.372±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
4.14±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Tiopinac (RS 40974), a dibenzthiepin, is an orally active and highly potent anti-inflammatory and anti-pyretic agent[1]. | [in vivo]
Tiopinac (0.03-110 mg/kg) has 40 times the antiphlogistic potency of phenylbutazone. The dose required to reduce paw swelling by 30% is approximately 0.5 mg/kg. Tiopinac does not elicit overt side effects at the 20 mg/kg/day dose. Tiopinac causes a dose-related reversal of the decreases body weight caused by the adjuvant disease, the weight of those rats receiving 0.135 and 0.4 mg/kg/day being significantly greater than that of the positive controls. Tiopinac (0.3-30 mg/kg) is highly potent in inhibiting the pain evoked in the yeastinflamed hind paw of the rat[1]. | [References]
[1] Rooks WH 2nd, et al. The anti-inflammatory and analgesic profile of 6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-acetic acid (tiopinac). Agents Actions. 1980 Jun;10(3):266-73. DOI:10.1007/BF02025946 |
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