| Identification | Back Directory | [Name]
D-Mannitol 1,6-bis(2-isocyano-3-methyl-2-butenoate) | [CAS]
61241-59-6 | [Synonyms]
32390A
A-32390A
Antibiotic A-32390A
D-Mannitol 1,6-bis(2-isocyano-3-methyl-2-butenoate)
1-O,6-O-Bis(2-isocyano-3-methyl-2-butenoyl)-D-mannitol | [MDL Number]
MFCD01939724 | [MOL File]
61241-59-6.mol |
| Hazard Information | Back Directory | [Uses]
A32390A is a dopamine β-hydroxylase inhibitor and copper chelator. A32390A can inhibit the synthesis of norepinephrine, which helps lower blood pressure in DOCA hypertensive rats. A32390A can be used in research on hypertension, bacterial infections, and metabolic disorders[1]. | [References]
[1] Zhu M, et al. Diisonitrile-Mediated Reactive Oxygen Species Accumulation Leads to Bacterial Growth Inhibition. J Nat Prod. 2020 May 22;83(5):1634-1640. DOI:10.1021/acs.jnatprod.0c00125
[2] Fuller RW, et al. New inhibitors of dopamine beta-hydroxylase. Adv Enzyme Regul. 1976;15:267-81. DOI:10.1016/0065-2571(77)90020-6 |
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