| Identification | Back Directory | [Name]
4-(3-Chloro-2-fluoroanilino)-6-hydroxy-7- methoxyquinazoline | [CAS]
612501-52-7 | [Synonyms]
4-(3-chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-ol
4-(3-Chloro-2-fluoroanilino)-6-hydroxy-7- methoxyquinazoline
6-Quinazolinol, 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy- | [Molecular Formula]
C15H11ClFN3O2 | [MDL Number]
MFCD26394834 | [MOL File]
612501-52-7.mol | [Molecular Weight]
319.72 |
| Chemical Properties | Back Directory | [Boiling point ]
458.9±45.0 °C(Predicted) | [density ]
1.489±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [pka]
8.17±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
Applications 4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-ol is a useful research chemical,it can be used as pharmaceutical intermediates. | [Synthesis]
4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate (200 mg) was used as starting material and dissolved in methanol (2 ml). Subsequently, aqueous ammonia solution (7N, 1 ml) was added to the reaction system. The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the solvent was removed by concentration under reduced pressure to afford the target product 4-((3-chloro-2-fluorophenyl)amino)-7-methoxy-6-ol (white solid, 176 mg, quantitative yield). | [References]
[1] Patent: CN108329276, 2018, A. Location in patent: Paragraph 0075; 0076
[2] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 18, p. 4455 - 4459
[3] Patent: WO2005/28469, 2005, A1. Location in patent: Page/Page column 59
[4] Patent: WO2005/28470, 2005, A1. Location in patent: Page/Page column 54
[5] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 18, p. 4908 - 4912 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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