| Identification | Back Directory | [Name]
Merck-22-6 | [CAS]
612847-42-4 | [Synonyms]
Merck-22-6 Merck-22-6 >=95% Merck-22-6 (KRC380) 6-Quinoxalinecarboxamide, N-[2-(diethylamino)ethyl]-3-[4-[[4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]methyl]phenyl]-2-phenyl- N-(2-(diethylamino)ethyl)-3-(4-((4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)methyl)phenyl)-2-phenylquinoxaline-6-carboxamide | [Molecular Formula]
C40H43N7O2 | [MDL Number]
MFCD21608460 | [MOL File]
612847-42-4.mol | [Molecular Weight]
653.82 |
| Hazard Information | Back Directory | [Description]
Merck-22-6 is an allosteric dual Akt1, Akt2 inhibitor. | [Uses]
Akt1/Akt2-IN-2 (compound 7) is an allosteric dual Akt1 and Akt2 inhibitor (IC50=138 nM and 212 nM, respectively). Akt1/Akt2-IN-2 increases activity of caspase-3, and inhibits viability of a number of tumor cells[1]. | [IC 50]
Akt1: 138 nM (IC50); Akt2: 212 nM (IC50); Akt3: 7.2 mM (IC50); Caspase-3 | [References]
[1] Zhao Z, et al. Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activity. Bioorg Med Chem Lett. 2008 Jan 1;18(1):49-53. DOI:10.1016/j.bmcl.2007.11.015 |
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Lynnchem
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86-(0)29-85992781 17792393971 |
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Novachemistry
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Creative Enzymes
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www.creative-enzymes.com |
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